李華[華中科技大學同濟藥學院生物藥學系主任]

李華，男，美國布朗大學分子生物學暨生物化學博士，華中科技大學同濟藥學院生物藥學系主任 ；瀋陽藥科大學中藥學院院長、博士生導師、教授 。

個人簡歷

李華，男，博士，教授。本科畢業於瀋陽藥科大學日語藥學專業，中國協和醫科大學獲得藥理學碩士，美國東北大學(Northeastern University)獲得有機化學碩士，美國布朗大學(Brown University)獲得分子生物學暨生物化學博士學位，而後在霍華德休斯醫學研究所(Howard Hughes Medical Institute)/德克薩斯大學西南醫學中心(UT Southwestern Medical Center)進行膜蛋白結構生物學的博士後研究。2013年起被華中科技大學同濟藥學院聘為教授、博士生導師。2015年10月起擔任瀋陽藥科大學中藥學院院長，教授、博士生導師 。

主要成就

1.全國中醫藥高等教育研究會中藥教育研究會副理事長

2. 中國中藥學會中藥新技術專業委員會專家組成員

3. 湖北省晶體學會秘書長兼副理事長

研究方向

研究方向一：重大疾病相關蛋白質的結構生物學

研究方向二：基於蛋白質結構的天然產物作用靶點和機制研究

研究方向三：基於結構的藥物設計與發現

代表論文

1. Meng-Zhu Zheng, Wei-Guang Sun, Su-Yu Gao, Shan-Shan Luan, Dan Li, Ren-Qi Chen, Qian Zhang, Li-Xia Chen*, Jian-Geng Huang*, Hua Li*. Structure Based Discovery of Clomifene as a Potent Inhibitor of Cancer-Associated Mutant IDH1. Oncotarget, 2017,doi:10.18632/oncotarget.17464. (SCI, IF 5.008)

2. Meng-Zhu Zheng, Shan-Shan Luan, Su-Yu Gao, Li Cheng, Bin Hao, Jia-Cheng Li, Yao Chen, Xue-Mei Hou*, Li-Xia Chen*, Hua Li*. Proton Pump Inhibitor Ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase, Oncotarget. 2017, doi: 10.18632/oncotarget.16609. (SCI, IF 5.008)

3. Wei Li, Meng-Zhu Zhang, Shuang-Ping Wu, Su-Yu Gao, Mei Yang, Zhi-Mei Li, Xiu-Xia Min, Wei-Guang Sun, Li-Xia Chen*, Guang-Ya Xiang*, Hua Li*. Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2. Journal of Experimental &Clinical Cancer Research, 2017, DOI: 10.1186/s13046-017-0530-4. (SCI, IF 4.357)

4. Yan He, Meng-Zhu Zheng, Qin Li, Zheng-Xi Hu, Hu-Cheng Zhu, Jun-Jun Liu, Jian-Ping Wang, Yong-Bo Xue*, Hua Li*, Yong-Hui Zhang*. Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1, Organic Chemistry Frontier, 2017, doi.org/10.1039/C6QO00847J. (SCI, IF 4.693)

5. Qiu-Xia Min, Xin-Pei Cai, Wei-Guang Sun, Fei Gao, Zhi-Mei Li, Qian Zhang, Luo-Sheng Wan, Hua Li*, Jia-Chun Chen*. Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening. Scientific Reports. 2017, DOI: 10.1038/srep44681. (SCI, IF 5.228)

6. Li-Qing Wang, Ying Wang, Su-Yu Gao, Li-Han Zhu, Fei Wang, Hua Li*, Li-Xia Chen*. Phenolic amides with anti-Parkinson’sdisease (PD) effects from Nicandra physaloides. Journal of Functional Foods (2017), doi: 10.1016/j.jff.2017.01.045. (SCI, IF 3.973)

7. Wei-Guang Sun, Xin-Tao Chen, Qing-Yi Tong, Hu-Cheng Zhu, Yan He, Lei Liang, Yong-Bo Xue, Guang-Min Yao, Zeng-Wei Luo, Jian-Ping Wang, Hua Li*, Yong-Hui Zhang*. Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune. Scientific Reports. 2016, 6, 26418, doi: 10.1038/srep26418. (SCI, IF 5.228)

8. Yan He, Jun Tian, Xin-Tao Chen, Wei-Guang Sun, Hu-Cheng Zhu, Qin Li, Liang Lei, Guang-Min Yao, Yong-Bo Xue, Jian-Ping Wang, Hua Li*, Yong-Hui Zhang*. Fungal naphtho-γ-pyrones: Potent antibiotics for drug-resistant microbial pathogens. Scientific Reports. 2016, 6, 24291, doi: 10.1038/srep24291. (SCI, IF 5.228)

9. Xiao-Yu Zeng, Lin Liu, Meng-Zhu Zheng, Hui-Min Sun, Luan-Juan Xiao, Tao Lu, Guang-Qian Huang, Pian-Pian Chen, Jian-Min Zhang, Feng Zhu*, Hua Li*, Qiu-Hong Duan*. Pantoprazole, a FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated proteinkinase. Oncotarget. 2016, doi: 10.18632/oncotarget.7984. (SCI, IF 5.008)

10. Liao, J*; Li, H*; Zeng, W; Sauer, DB; Belmares, R; Jiang, Y. Structural Insight into the Ion Exchange Mechanism of Sodium/Calcium Exchanger. Science. 2012, 335: 686-690. (SCI, IF 34.661)