人物信息
•姓名：李彥伸
•籍貫：山東煙臺
•最後學歷：博士
•最後畢業院校：中國農業大學
•工作單位：煙臺大學生命科學學院
•職稱：副教授
學習經歷
2003.09-2008.07 南京農業大學學士
2008.08-2013.06 中國農業大學博士
指導教師：張素霞（教授）
吳永寧（國家食品安全風險評估中心技術總師）
研究方向
真菌毒素及藥物代謝及遷移轉化規律研究
微生物檢測及新型抗生素研究
藥物殘留分析及快速檢測
講授課程
食品化學，儀器分析，食品安全綜合實驗
科研項目
2018.04-2021.03主持“國家重點研發計畫——國際合作”課題《中歐食品安全合作H2020EU-China-Safe》，項目資助總金額1741萬元（2017YFE0110800）
2015.01-2017.12主持“國家自然科學基金-青年基金項目”《多種單端孢霉烯族毒素在大鼠體內體外聯合代謝的研究》資助金額24萬（31402246）
2009.01-2014.12“973”項目《畜禽產品中有害物質形成原理與控制途徑研究》（2009CB118801）
2015.01-2018.12山東省自然科學基金項目
《RAS與AT1R/p38MAPK通路在糖尿病心肌纖維化中互動作用及LXRα的干預研究》
《miRNA-27a調控環路介導的糖尿病心肌纖維化新機制及氟非尼酮干預研究》
《燒肉加工過程中風味物質形成機制研究及氣味指紋圖譜的構建》
獲獎情況
2017年山東省研究生實踐成果獎
2016年，2017年煙臺大學自然科學獎
代表論著
共發表學術論文 42 篇，其中 SCI 收錄 32 篇， 1 篇為高被引論文
[1] 2018:Shupeng Yang, Xiujuan Yi, Xin Mao, Yunguo Liu, Suxia Zhang, Yanshen Li*. Integrated immunoassay-based broad detection of multi-class mycotoxins. Food and Agricultural Immunology.2018 Accepted
[2] 2018:Yanshen Li,Zhenhua Yu, Yong Cui, Hui Sun, Jin Li, Kun Yin, Guihua Zhao, Hongfa Wang, Bingcheng Huang, Qingkuan Wei, Gongzhen Liu,Jingxuan Kou. Identification of A Novel Host Protein Interacting with Toxoplasma Gondii Toxofilin via A Yeast two-hybrid system. Acta Biochimica Et Biophysica Sinica.2018, 50(4), 425–427.
[3] 2018:Yanshen Li*, Guizhen Zhang, Xin Mao, Shupeng Yang, Karl De Ruyck, Yongning Wu. High Sensitivity Immunoassays for Small Molecule Compounds Detection – NovelNoncompetitive Immunoassay Designs. Trends in Analytical Chemistry.2018, 103, 198-208
[4] 2018:Huihui Liu,Chuanbo Ren, Dianfeng Han, Hui Huang, Rongjie Zou, Huawei Zhang, Yingjiang Xu, Xianghong Gong, Xiuzhen Zhang, and Yanshen Li*. UPLC-MS/MS Method for Simultaneous Determination of Three Major Metabolites of Mequindox in Holothurian. Journal of Analytical Methods in Chemistry.2018. Article ID 2768047, 1-7
[5] 2018 ：Feifei Sun, Huiyan Zhang, Gerard Bryan Gonzales, Jinhui Zhou, Yi Li, Jinzhen Zhang, YueJin, Zhanhui Wang, Yanshen Li,Xingyuan Cao, Suxia Zhang, Shupeng Yang. Unravelling the Metabolic Routes of Retapamulin: Insights into Drug Development of Pleuromutilins. Antimicrobial Agents & Chemotherapy.2018. Accepted online.
[6] 2018:Gongzhen Liu, Yanshen Li,Yong Cui,Bingcheng Huang, Hongfa Wang, Yanping Chen, Jingxuan Kou, Fuyong Wang, Chongxing Zhang, Yong Huang, Yin Li, Meng Wang, Qingkuan Wei, Jin Li, Hui Sun, Kun Yin, Guihua Zhao, Yan Jiang, Xin Mao, Zhenhua Yu, Xin Liu. Cysticercosis in Shandong Province, Eastern China. Emerging Infectious Diseases,2018, 4, 384-385
[7] 2018:Ziping Zhang, Cancan Tao, Jungang Yin, Yunhui Wang, Yanshen Li.Enhancing the Response Rate of Strand Displacement-Based Electrochemical Aptamer Sensors Using Bivalent Binding Aptamer-Cdna Probes. Biosensors and Bioelectronics.2018, 103, 39-44.
[8] 2017: Yanshen Li*Jing Zhang, Yunhui Wang, Xin Mao, Huihui Liu. Immunity Theory-Based High-Specific Monoclonal Antibody Preparation and Application of Fumonisin B1. Food Analytical Methods.2017,10(10): 3361–3367. DOI: 10.1007/s12161-017-0912-4.
[9] 2017:Jianrong Yang, Rui Zhao, Liting Song, Jungang Yin, Yanli You, Chengfeng Sun, Yanshen Li*. Optimized Ultrasonic-Assisted Extraction of Aflatoxin B1 from Peanuts with Response Surface Methodology. Analytical Letters.2017, 50(4), 629-640. DOI: 10.1080/00032719.2016.1190978.
[10] 2017: Yanshen Li*, Jing Zhang, Xin Mao, Yongtao Wu, Gongzhen Liu, Liting Song, Yonggang Li, Jianrong Yang, Yanli You, Xuelin Cao. High-sensitive Chemiluminescent Immunoassay Investigation and Application for the Detection of T-2 Toxin and Major Metabolite HT-2 Toxin. Journal of the Science of Food and Agriculture.2017, 97(3): 818-822. DOI: 10.1002/jsfa.7801.
[11] 2017:Shupeng Yang, Huiyan Zhang, Feifei Sun, Karl De Ruyck, Jinzhen Zhang, Yue Jin, Yanshen Li, Zhanhui Wang, Suxia Zhang, Sarah De Saeger, Jinhui Zhou, Yi Li, Marthe De Boevre. Metabolic Profile of Zearalenone in Liver Microsomes from DifferentSpecies and Its in Vivo Metabolism in Rats and Chickens Using UltraHigh-Pressure Liquid Chromatography-Quadrupole/Time-of-FlightMass Spectrometry. Journal of Agricultural and Food Chemistry.2017, 65, 11292−11303
[12] 2017:Yonglin Gao, Chunmei Li, Yunzhi Wang, Yunguo Liu, Guisheng Li, Xiaochen Fan, Yanshen Li,Jingwei Tian, Albert W. Lee. Nonclinical Safety of Astilbin: A 4-Week Oral Toxicity Study in Rats With Genotoxicity, Chromosomal Aberration, and Mammalian Micronucleus Tests. Food and Chemical Toxicology.2017, 107, 1-9. DOI: 10.1016/j.fct.2017.06.024.
[13] 2017:Yonglin Gao, Yunzhi Wang, Yanshen Li,Rui Han, Chunmei Li, Lin Xiao, Susan Cho, Yukui Ma, Chao Fang, Albert W. Lee. Repeated Sub-Chronic Oral Toxicity Study of Xylooligosaccharides (XOS) in Dogs. Regulatory Toxicology and Pharmacology.2017, 86, 379-385. DOI: 10.1016/j.yrtph.2017.04.009.
[14] 2017:Chunmei Li, Yonglin Gao, Yunzhi Wang, Guisheng Li, Xiaochen Fan, Yanshen Li,Chenghua Guo, Jun Tao. Genotoxicity Testing of Sodium Formononetin-3’-Sulphonate (Sul-F) by Assessing Bacterial Reverse Mutation, Chromosomal Aberrations and Micronucleus Tests. Regulatory Toxicology and Pharmacology.2017, 86, 374-378. DOI: 10.1016/j.yrtph.2017.04.005.
[15] 2017:Shupeng Yang, Marthe De Boevre, Huiyan Zhang, Karl De Ruyck, Feifei Sun, Jinzhen Zhang, Yue Jin, Yanshen Li,Zhanhui Wang, Suxia Zhang, Jinhui Zhou, Yi Li, Sarah De Saeger. Metabolism of T-2 Toxin in Farm Animals and Human In Vitro and in Chickens In Vivo Using Ultra High-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Hybrid Mass Spectrometry Along with Online Hydrogen/Deuterium Exchange Technique. Journal of Agricultural and Food Chemistry.2017, 65 (33), 7217–7227. DOI: 10.1021/acs.jafc.7b02575
[16] 2017:Feifei Sun, Shupeng Yang, Huiyan Zhang, Jinhui Zhou, Yi Li, Jinzhen Zhang, Yue Jin, Zhanhui Wang, Yanshen Li, Jianzhong Shen, Suxia Zhang, Xingyuan Cao. Comprehensive Analysis of Tiamulin Metabolites in Various Species of Farm Animals Using Ultra-High-Performance Liquid Chromatography Coupled to Quadrupole/Time-of-Flight. Journal of Agricultural and Food Chemistry.2017, 65 (1), 199–207. DOI: 10.1021/acs.jafc.6b04377.
[17] 2017:Chunmei Li, Rui Han, Le Kang, Jianping Wang, Yonglin Gao, Yanshen Li, Jie He, Jingwei Tian. Pirfenidone Controls the Feedback Loop of the AT1R/P38 MAPK/Renin-Angiotensin System Axis by Regulating Liver X Receptor-Α In Myocardial Infarction-Induced Cardiac Fibrosis. Scientific Reports.2017, 7: 40523. DOI: 10.1038/srep40523.
[18] 2016:Yanli You, LitingSong, Yanshen Li*Yongtao Wu, Xin Mao. Simple and Fast Extraction-Coupled UPLC-MS/MS Method for the Determination of Mequindox and Its Major Metabolites in Food Animal Tissues. Journal of Agricultural and Food Chemistry.2016, 64(11): 2394-2404.DOI: 10.1021/acs.jafc.5b05903.
[19] 2015: Yanshen Li*,Gongzhen Liu, Xuejun Fu, Jun He, Zhanhui Wang, Jianhai Hou, Xingyuan Cao, Weimin Shi, Suxia Zhang. High-sensitive Chemiluminescent ELISA Method Investigation for the Determination of Deoxynivalenol in Rice. Food Analytical Methods.2015, 8(3), 656-660. DOI: 10.1007/s12161-014-9941-4
[20] 2014: Yanshen Li*,Kaili Liu, Ross C. Beier, XiangshuLuo, Jianzhong Shen, Suxia Zhang*. Simultaneous Determination of Mequindox, Quinocetone, and Their Major Metabolites in Chicken and Pork by Ultra-high Performance Liquid Chromatography–Tandem Mass Spectrometry. Food Chemistry.2014, 160(1): 171-179.DOI: 10.1016/j.foodchem.2014.03.094.
[21] 2014: Yanshen Li*,Xiangshu Luo, Shupeng Yang, Xingyuan Cao, Zhanhui Wang, Weimin Shi, and Suxia Zhang*. High Specific Monoclonal Antibody Production and Development of an ELISA Method for Monitoring T-2 Toxin in Rice. Journal of Agricultural and Food Chemistry.2014, 62(7), 1492-1497. DOI: 10.1021/jf404818r.
[22] 2013 ： Yanshen Li,Peng Li, Xiangshu Luo, Zhihui Hao, Zhanhui Wang, Jianzhong Shen, Xingyuan Cao, Suxia Zhang*. Mixed Immunoassay Design for Multiple Chemical Residues Detection. Analytical & Bioanalytical Chemistry.2013, 405(10), 3307-3312:DOI: 10.1007/s00216-013-6780-x.
[23] 2013:Songqing Li, Yanshen Li,Ying Wang, Wenfeng Zhou, Haixiang Gao, Suxia Zhang*. Water-based Slow Injection Ultrasound-Assisted Emulsification Microextraction for the Determination of Deoxynivalenol and De-Epoxy-Deoxynivalenol in Maize and Pork Samples. Analytical & Bioanalytical Chemistry.2013, 405(12): 4307-4311. DOI: 10.1007/s00216-013-6792-6.
[24] 2013:Yang Shupeng, Li Yanshen,Cao Xingyuan, Hu Dingfei, Wang Zhanhuia, Wang Ying, Shen Jianzhong, Zhang Suxia*. Metabolic Pathways of T-2 Toxin in in vivo and in vitro Systems of Wistar Rats. Journal of Agricultural and Food Chemistry.2013, 61(40): 9734-9743. DOI: 10.1021/jf4012054.
[25] 2012:Yanshen Li, Yanrong Zhang, Weimin Shi, Zhanhui Wang, Jianzhong Shen, Suxia Zhang*. Determination of T-2 toxin and HT-2 toxin in milk A comparison of three formats of immunoassays. Analytical Letters.2012, 45: 2425-2435.DOI: 10.1080/00032719.2012.686134.
[26] 2012: Yanshen Li,Zhanhui Wang, Sarah De Saeger, Weimin Shi, Cun Li, Suxia Zhang, Xingyuan Cao, Jianzhong shen*. Determination of Deoxynivalenol in Cereals by Immunoaffinity and Ultra-high Performance Liquid Chromatography Tandem Mass Spectrometry. Methods.2012, 56(2): 192-197. DOI: 10.1016/j.ymeth.2011.10.009.
[27] 2012:Yanshen Li,Yanrong Xhang, Xingyuan Cao, Zhanhui Wang, Jianzhong Shen, Suxia Zhang*. Development of A Chemiluminescent Competitive Indirect ELISA Method Procedure for the Determination of Gentamicin in Milk. Analytical Methods.2012, 4, 2151-2155. DOI:10.1039/C2AY25141H.
[28] 2012: Yanshen Li,Weimin Shi, Jianzhong Shena, Suxia Zhanga, Linli Cheng, Zhanhui Wang*. Development of A Rapid Competitive Indirect ELISA Procedure for the Determination of Deoxynivalenol in Cereals. Food and Agricultural Immunology.2012, 23(1): 41-49. DOI:10.1080/09540105.2011.589046.
[29] 2012:Ying Wang, Xingyuan Cao, Yanshen Li, Shupeng Yang, Jianzhong Shen, Suxia Zhang*. Simultaneous Determination of Type-A and Type-B Trichothecenes in Rice by UPLC-MS/MS. Analytical Methods.2012, 4, 4077-4082. DOI: 10.1039/C2AY25755F.
[30] 2011: Yanshen Li,Zhanhui Wang, Ross C. Beier, Jianzhong Shen, David De Smet, Sarah De Saeger, and Suxia Zhang*. T-2 Toxin, ATrichothecene Mycotoxin: Review of Toxicity, Metabolism, and Analytical Methods. Journal of Agricultural and Food Chemistry.2011, 59, 3441-3453. DOI: 10.1021/jf200767q. （高被引論文）
[31] 2010:Jianzhong Shen, Chunyan Yang, Congming Wu, Peisheng Feng, Zhanhui Wang, Yan Li, Yanshen Li,and Suxia Zhang*. Identification of the Major Metabolites of Quinocetone in Swine Urine Using Ultra-Performance Liquid Chromatography Electrospray Ionization Quadrupole Time-of-flight Tandem Mass Spectrometry. Rapid Communications in Mass Spectrometry.2010, 24, 375-383. DOI: 10.1002/rcm.4399.
[32] 2009:Cong-Ming Wu, Yan Li, Jian-Zhong Shen, Lin-Li Cheng, Yan-Shen Li,Chun-Yan Yang, Pei-Sheng Feng, Su-Xia Zhang*. LC–MS–MS Quantification of Four Quinoxaline-1, 4-Dioxides in Swine Feed. Chromatographia.2009, 70, 1605-1611.DOI: 10.1365/s10337-009-1359-6.
