![李偉[吉林農業大學中藥材學院]](/img/0/5d8/nBnauM3XzgjM3MzN0kDOxIDN0UTMyITNykTO0EDMwAjMwUzL5gzLwMzLt92YucmbvRWdo5Cd0FmLyE2LvoDc0RHa.jpg "李偉[吉林農業大學中藥材學院]")
人物介紹
近年來，先後對人參、桔梗、五味子等多種長白山藥用植物進行化學成分及藥理活性研究，在《J Agr Food Chem》，《Food Chem Toxicol》和《Phytotherapy Res》等國內外期刊發表學術論文100餘篇，其中SCI收錄75篇；申請發明專利30項，授權11項。指導碩士研究生30名，承擔本科生和研究生《中藥鑑定學》和《中藥加工與炮製》等課程，吉林省優秀課《中藥鑑定學》帶頭人。先後主持國家自然科學基金、博士後面上基金和吉林省科技科技發展計畫等6項科研課題。獲得吉林省科技進步三等獎1項，吉林省自然科學學術成果一等獎1項，二等獎3項，長春市級科技進步一等獎和三等獎各1項。主/參編《金銀花標準化加工與利用》、《中國藥用植物志》等多部著作及教材
工作經歷
2000.9-2004.7 吉林農業大學中藥材學院，中藥學專業，獲得理學學士學位
2004.9-2007.7 吉林農業大學中藥材學院，中藥學專業，醫學碩士，主要從事植物化學成分分離與鑑定，導師，鄭毅男，教授
2009.7-2012.6 吉林大學白求恩醫學院，藥理學，醫學博士，主要從事內分泌藥理學，導師，陳立，教授
2012.8-現在 中國農業科學研特產研究所，博士後，主要從事人參次生代謝產物及生物活性，導師，王英平，研究員
2014.8-2015.8 澳大利亞The University of Queensland訪問學者，研究方向，天然產物分子內分泌，合作導師chenchen教授。
2007.9-現在 吉林農業大學中藥材學院，中藥學專業，講師，副教授，教授（破格）
研究方向
1、藥用植物資源開發與利用
代表性論文
Zhou Yan-dan, Hou Jin-gang, Liu Wei, Ren Shen, Wang Ying-ping, Zhang Rui, Chen Chen, Wang Zi*, Li Wei*. 20(R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis. International Immunopharmacology, 2018, 59, 21-30.
Li Wei*, Chen Chen. Response to the Comments on Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice. J Agric Food Chem. 2018, 66(7):1734-1735.
Hu Jun-Nan, Xu Xing-Yue,Li Wei*, Wang Yi-Ming, Liu Ying, Wang Zi, Wang Ying-Ping. Ginsenoside Rk1 ameliorates acetaminophen-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis. J Ginseng Res, 2017.
Hou Jin-gang, Xue Jian-jie, Zhao Xing-hua, Wang Zi, Li Wei*, Li Xin-dian, Zheng Yi-nan. Octyl ester of ginsenoside compound K as novel anti-hepatoma compound: synthesis and evaluation on murine H22 cells in vitroand in vivo, Chem Biol Drug Des, 2018.91(4):951-956
Ma Zhi-na, Zhi Liu, Wang Zi, Ren Shen, Tang Shan, Wang Ying-ping, Xiao Sheng-yuan, Chen Chen, and Li Wei*. Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways,Food Chemical Toxicology, 2017.110, 62-73.
Wang Zi, Hu Jun-nan, Yan Meng-han, Xing Jing-jing, Liu Wen-cong, Li Wei*. Caspase-mediated anti-apoptotic effect of Ginsenoside Rg5, a main rare ginsenoside, on Acetaminophen-induced Hepatotoxicity in Mice. J Agric Food Chem.2017,65(42):9226-9236.
Ma Zhi-na, Li Yan-zi, Li Wei*, Yan Xiao-tong, Yang Ge, Zhang Jing, Zhao Li-chun, Yang Li-min. Nephroprotective effects of Saponins from leaves of Panax quinquefoliusagainst cisplatin-induced acute kidney injury. Int. J. Mol. Sci. 2017, 18(7), 1407.
Qi Zhen-lan, Wang Zi,Li Wei*, Hou Jin-gang, Liu Ying, Li Xin-dian, Li Hui-ping, Wang Ying-Ping. Nephroprotective effects of Anthocyanins from the fruits of Panax ginseng(GFA) on cisplatin-induced acute kidney injury in mice. Phytotherapy Research. 2017,31: 1400-1409
Xu Xing-yue, Hu Jun-nan, Liu Zhi, Zhang Rui, He Yu-fang, Hou Wei, Wang Zhi-qing, Yang Ge, Li Wei*. Saponins (ginsenosides) from the Leaves of Panax QuinquefoliusAmeliorated Acetaminophen-Induced Hepatotoxicity in Mice. J Agric Food Chem.2017, 65(18):3684-3692.
Hu Jun-Nan, Liu Zhi, Wang Zi, Li Xin-Dian, Zhang Lian-Xue, Li Wei*, Wang Ying-Ping. Ameliorative Effects and Possible Molecular Mechanism of Action of Black Ginseng (Panax ginseng) on Acetaminophen-Mediated Liver Injury. Molecules, 2017, 22(4), 664.
Liu Zhi, Wang Chong-Zhi, Zhu Xing-You, Wan Jin-Yi, Zhang Jing, Li Wei*, Ruan Chang-Chun (*), Yuan Chun-Su. Dynamic Changes in Neutral and Acidic Ginsenosides with Different Cultivation Ages and Harvest Seasons: Identification of Chemical Characteristics for Panax ginsengQuality Control,Molecules, 2017, 22(5), 734.
Han Xin-yue, Hu Jun-nan, Wang Zi, Wei Sheng-nan, Zheng Si-wen, Wang Ying-ping, Li Wei *. 5-HMF Attenuates Liver Fibrosis in CCl4-Plus-Alcohol-Induced Mice by Suppression of Oxidative Stress. Journal of Nutritional Science and Vitaminology, 2017, 63(1):135-143.
Li Wei, Qu Xin-Nan, Han Ye, Zheng Si-Wen, Wang Jia, and Wang Ying-Ping. Ameliorative Effect of 5-hydroxymethyl-2-furfural (5-HMF) on Acute Alcoholic Liver Oxidative Injury in Mice.Int. J. Mol. Sci. 2015, 16(2): 2446-2457.
Li Wei, Yan Meng-Han, Liu Ying, Liu Zhi, Wang Zi, Chen Chen, Zhang Jing, Sun Yin-Shi. Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis. Nutrients, 2016, 8(9), 566.
Li Wei, Tian Yu-Hong, Liu Ying, Wang Zi, Tang Shan, Zhang Jing, Wang Ying-Ping. Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. The Journal of Toxicological Sciences, 2016, 41(3):417-428.
Li Wei, Su Xiao-min, Han Ye, Xu Qi, Zhang Jing, Wang Zi, Wang Ying-ping. Maltol, a Maillard reaction product, exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis, RSC Adv., 2015, 5(123), 101850-101859.
Li Wei, Xu Qi, He Yu-Fang, Liu Ying, Yang Shu-Bao, Wang Zi, Zhang Jing, Zhao Li-Chun. Anti-Tumor Effect of Steamed Codonopsis lanceolata in H22 Tumor-Bearing Mice and Its Possible Mechanism. Nutrients, 2015, 7(10):8294-8307.
Li Wei, Liu Ying, Wang Zi, Han Ye, Tian Yu-hong, Zhang Gui-shan, Sun Yin-shi, Wang Ying-ping. Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice,Food & Function, 2015, 6(5): 1418-1427.
Li Wei; Zhao Li-Chun, Sun Yin-Shi, Lei Feng-Jie, Wang Zi, Gui Xiong-Bin, Wang Hui. Optimization of Pressurized Liquid Extraction of Three Major Acetophenones from Cynanchum bungei using a Box-Behnken Design. Int. J. Mol. Sci. 2012, 13(11), 14533-14544.
Li Wei, Zhang Ming, Gu Jian, Meng Zhao-jie, Wang Ying-ping, Chen Li, Zheng Yi-nan. Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 Diabetes mice induced by High-Fat Diet combining with Streptozotocin via suppression of hepatic gluconeogenesis. Fitoterapia. 2012, 83(1):192-198.
Li Wei, Zhao Li-chun, Wang Zi, Zheng Yi-nan, Jian Liang, Wang Hui. Response Surface Methodology to Optimize Enzymatic Preparation of Deapio-platycodin D and Platycodin D from Radix Platycodi. Int. J. Mol. Sci. 2012, 13(4):4089-4100.
Li Wei, Wang Zi, Wang Ying-ping, Jiang Chao, Liu Qun, Sun Yin-shi, Zheng Yi-nan.Pressurized liquid extraction combining LC-DAD-ESI/MS analysis as an alternative method to extract three major flavones in Citrus reticulata ‘Chachi’ (Guangchenpi), Food Chemistry. 2012, 130(4):1044-1049.
Li Wei, Sun Yin-shi, Wang Zi, Zheng Yi-nan. Isolation and purification of saponins from Platycodon grandiflorum by semi-preparative high performance liquid chromatography and LC/ESI-MS. Journal of Liquid Chromatography & Related Technologies. 2012, 35(4):547-557.
Li Wei, Zhang Ming, Wang Zi, Zheng Yi-nan, Wang Ying-ping, Zhang Jing. Simultaneous RP-HPLC Determination of Six Platycosides: Application to an Enzymatic Preparation Study. Chromatographia. 2011, 74(11-12):777-782.
Li Wei, Zhang Ming, Zheng Yi-nan, Li Jing, Wang Ying-ping, Wang Yun-jing, Gu Jian, Jin Ying, Wang Hui, Chen Li. Snailase Preparation of Ginsenoside M1 from Protopanaxadiol-Type Ginsenoside and Their Protective Effects Against CCl-Induced Chronic Hepatotoxicity in Mice. Molecules. 2011, 16(12):10093-10103.
Li Wei, Wang Zi, Sun Yin-shi, Chen Li, Han Li-kun, Zheng Yi-nan. Application of response surface methodology to optimize ultrasonic-assisted extraction of four chromones in Radix Saposhnikoviae, Phytochemical Analysis, 2011, 22(4):313-321.
Li Wei, Zhang Wei, Xiang Lan, Wang Zi, Zheng Yi-nan, Wang Ying-ping, Zhang Jing, Chen Li. Platycoside N: A New Oleanane-Type Triterpenoid Saponin from the Roots of Platycodon grandiflorum. Molecules. 2010, 15(12):8702-8708.
Li Wei, Liu Zheng-bo, Wang Zi, Chen Li, Sun Yin-shi, Hou Jin-gang, Zheng Yi-nan. Application of accelerated solvent extraction to the investigation of saikosaponins from the roots of Bupleurum falcatum. J Sep Sci. 2010, 33(12):1870-1876.
Li Wei, Wang Zi, Chen Li, Zhang Jing, Han Li-kun, Hou Jin-gang, Zheng Yi-nan. Pressurized liquid extraction followed by LC-ESI/MS for analysis of four chromones in Radix Saposhnikoviae. J.Sep. Sci. 2010, 33(17-18):2881-2887.
Li Wei, Xiang Lan, Zhang Jing, Zheng Yi-nan, Han Li-kun, Saitoc Masato. A New triterpenoid saponin from the roots of Platycodon grandiflorum. Chin Chem Lett, 2007, 18(3):306-308.
Li Wei, Shi lei-ling, Han li-qin, Zhang Jing. Development and validation of a RP-HPLC method for simultaneous determination of salicin and eight flavonoids in leaves of Salix matsudana Koidz. Acta Chromatographica. 2013, 25(4):735-743.
Han Ye, Xu Qi, Hu Jiang-ning, Han Xin-yue,Li Wei (*), Zhao Li-Chun. Maltol, a Food Flavoring Agent, Attenuates Acute Alcohol-induced Oxidative Damage in Mice. Nutrients, 2015, 7(1): 682-696.
He YF, Nan ML, Sun JM, Meng ZJ, Li Wei (*), Zhang M. Design, Synthesis and Cytotoxicity of Cell Death Mechanism of Rotundic Acid Derivatives, Bioorganic & Medicinal Chemistry Letters, 2013, 23(9):2543–2547.
Gu Jian, Li Wei (Co-first author), Xiao Dong, Compound K, a final intestinal metabolite of ginsenosides, enhances insulin secretion in MIN6 pancreatic β-cells by upregulation of GLUT2.Fitoterapia. 2013, 83(1):192-198.
Guan Feng Ying, Gu Jian, Li Wei, Zhang Ming, Ji Yingshi, Li Jing, Chen Li, M. Hatch Grant. Compound K protects pancreatic islet cells against apoptosis through inhibition of the AMPK/JNK pathway in type 2 diabetic mice and in MIN6 β-cells. Life Sciences, 2014 27(1-2):42-49
1.Li Wei
2.Li Wei
3.Li Wei*
4.Li Wei*
5.Li Wei
6.Li Wei*
7.Li Wei*
8.Li Wei*
9.Xu Xing-yue, Hu Jun-nan, Liu Zhi, Zhang Rui, He Yu-fang, Hou Wei, Wang Zhi-qing, Yang Ge, Li Wei*. Saponins (ginsenosides) from the Leaves of Panax QuinquefoliusAmeliorated Acetaminophen-Induced Hepatotoxicity in Mice. J Agric Food Chem.2017, 65(18):3684-3692.
10.Li Wei*
11.Li Wei*
12.Li Wei *
13.Li Wei
14.Li Wei
15.Li Wei
16.Li Wei
17.Li Wei
18.Li Wei
19.Li Wei
20.Li Wei
21.Li Wei
22.Li Wei
23.Li Wei
24.Li Wei
25.Li Wei
26.Li Wei
27.Li Wei
28.Li Wei
29.Li Wei,
30.Li Wei
31.Li Wei
32.Li Wei
33.Li Wei (*)
34.Li Wei (Co-first author)
35.Li Wei
主要著作
主編，金銀花標準化生產及加工利用，化學工業出版社，2013年12月， 19萬字，ISBN：9787122192332。
副主編，林下參栽培技術，吉林科學技術出版社/吉林出版集團，2013年6月，ISBN 978-7-5384-6914-1
參編，中國藥用植物志，姜科等，2012年，北京大學出版社。
1.主編，金銀花標準化生產及加工利用，化學工業出版社，2013年12月， 19萬字，ISBN：9787122192332。
2.副主編，林下參栽培技術，吉林科學技術出版社/吉林出版集團，2013年6月，ISBN 978-7-5384-6914-1
3.參編，中國藥用植物志，姜科等，2012年，北京大學出版社。
科研獲獎
[1]. 中藥有效成分快速提取，吉林省自然科學學術成果獎，一等獎，第一完成人，2012年。NO.20121025
[2]. 桔梗中皂苷類成分的分離、製備、測定及生物轉化，吉林省自然科學學術成果獎，二等獎，第一完成人。2013年，NO. 20132113
[3]. 救必應酸的製備及其衍生物的設計、合成及抗腫瘤活性的系列研究，吉林省自然科學學術成果獎，二等獎，第三完成人。2014年，NO. 20142127
[4]. 回響曲面法最佳化酶轉化製備白藜蘆醇的工藝最佳化，吉林省自然科學學術成果獎，三等獎，第三完成人，2014年，NO.20143121
[5]. 抗腫瘤人參皂苷M1衍生物的合成及結構最佳化, NO. 20120F-1-06-09，大連市科技進步一等獎，第9名，2012年。
[6]. 桔梗種質資源評價、品種選育及高效利用，長春市科技進步三等獎，第二名，2014年，NO.21014030402
