研究領域及取得成果介紹
美麗的植物螢光顯微照片 2000年開始從事雙光子方面的工作，在雙光子聚合方面已經取得了較大的成績。目前的工作集中在雙光子生物螢光探針的設計、製備和生物套用研究。此領域是一項多學科密集交叉的國際前沿領域，正在力爭在該領域作出創造性的工作。經過十年的建設，實驗室擁有先進有機材料製備、螢光性能表征、雙光子性能測試、活性生物細胞與組織培育、生物螢光顯微成像等一流設備。特別是雙光子螢光測試系統、雙光子生物螢光顯微系統是我們根據生物螢光探針的實驗要求自行建設的，並得到了國際國內同行的認可，我們的實驗數據已經為浙江大學、中國科學院化學研究所、吉林大學、中國海洋大學、重慶大學等單位提供數據，並協助其發表論文。
主要承擔的科研課題
(1) 雙光子光聚合反應的研究 國家自然科學基金委員會
(2) 聚合物型三維光子晶體的雷射微加工和微型光學器件研究 國家自然科學基金委員會/香港資助局聯合資助
(3) 生物學光學視窗的水溶性雙光子螢光材料研究及相關核酸探針的探索 國家自然科學基金委員會
(4) 光波段具有負折射特性的特殊周期介質結構的研究 科技部973基礎研究課題
(5)雙光子DNA探針的研製 濟南試豪生物公司自主專利資助課題
作者論文發表情況
Hong Xia, Jie Yang, Hong-Hua Fang, Qi-Dai Chen, Hai-Yu Wang, Xiao-Qiang Yu, Yu-Guang Ma, Min-Hua Jiang, and Hong-Bo Sun Efficient two-photon excited amplified spontaneous emission from organic single crystalsChemPhysChem2010 accepted
賈鵬飛, 劉恆, 張元紅,劉鑫, 趙寧,於曉強2,7-BHVC，一個新的用於細胞核成像的雙光子螢光探針高等學校化學學報，2010 接收
Zhang, Xian, Sun, Yuming, Yu, Xiaoqiang, Zhang, Baoqin, Huang, Baibiao, Jiang, Minhua. Synthesis and nonlinear optical properties of several new two-photon photopolymerization initiators about dibenzothiophene derivatives.Synth. Met.159, 2491–2496. (2009)
劉鑫, 劉恆, 賈鵬飛, 張波, 王軍傑, 趙寧, 張元紅, 於曉強一種新型的用於細胞核成像的雙光子螢光探針 高等學校化學學報，30(3) 465-467 (2009)
Yi Dong, Xiaoqiang Yu, Yuming Sun, Yufei Li, Xueyuan Hou, Xian Zhang. Polymer waveguide grating fabricated by two-photon initiated photopolymerization and its application as an input coupler.Opt. Mater. 30, 935–938, (2008)
Xian Zhang, Xiaoqiang Yu, JinShui Yao, Minhua Jiang. Synthesis and nonlinear optical properties of two three-branched two-photon polymerization initiators.Synth. Mat. 158, 964–968, (2008)
Y. Dong, Y.M. Sun, Y. F. Li, X.Q. Yu, X.Y. Hou, X. Zhang. The fabrication of index-modulated grating coupler in a polymeric waveguide using two-photon initiated photopolymerization.Thin Sol. Films516, 1214–1217, (2008)
於曉強， 陶緒堂，蔣民華. 雙光子生物螢光顯微技術中的探針問題（綜述）. 大學化學，23, 1–7, (2008)
Wang, Jun Jie, Zhang, Xian, Zhang, Bao Qin, Wang, Gang, Yu, Xiao Qiang9-Ethyl-3,6-diformyl-9H-carbazole Acta Crystallographica Section E 64 O1293-U2180(2008)
Yi Dong, Xiaoqiang Yu, Yuming Sun, Xueyuan Hou, Yufei Li, Xian Zhang. Refractive index-modulated grating in two-mode planar polymeric waveguide produced by two-photon Polymerization.Polym. Adv. Technol. 18, 519–521, (2007)
Shen Xiao-Xia, Yu Xiao-Qiang, Yang Xiu-Lun, Cai Lv-Zhong, Wang Yu-Rong, Dong Guo-Yan, Meng Xiang-Feng, Xu Xian-Feng Fabrication of two-dimensional photonic crystals with controlled defects by combination of holographic lithography and two-photon polymerizationChinese Physics Letters24(11), 3160-3163, (2007)
Xian Zhang, XiaoQiang Yu, YuMing Sun, HongYan Xu, YunGuo Feng, BoBiao Huang, XuTang Tao, MinHua Jiang. Synthesis, structure and nonlinear optical properties of two new one and two-branch two-photon polymerization initiators.Chem. Phys. 328, 103–110, (2006)
Xiao Qiang YU, Xian ZHANG, Gui Bao XU, Hua Ping ZHAO, Wei HE, Zong Shu SHAO, Xian Gang XU, Min Hua JIANG. The Up-conversion Laser Properties of a Non-polar Organic Dye and the Influence of Solvents and Pumping Wavelengths.Chin. Chem. Lett. 17, 81–84, (2006)
Xian Zhang, Xiaoqiang Yu, Yuming Sun, Wei He, Yongzhong Wu, Yunguo Feng, Xutang Tao, Minhua Jiang, Synthesis and nonlinear optical properties of two new two-photon initiators: Triphenylamine derivatives.Opt. Mater. 28, 1366–1371, (2006)
ZHANG Xian, YU Xiao-Qiang, ZHANG Bao-Qin, FENG Yun-Guo, TAO Xu-TANG, JIANG Min-Hua, Synthesis and nonlinear optical properties of a new D--A two-photon polymerization initiator: DPAMOB with a lager TPA cross-section.Chin. J. Chem. 24, 701–704, (2006)
X X Shen, X Q Yu, X L Yang, L Z Cai, Y R Wang, G Y Dong, X F Meng, X F Xu. Fabrication of periodic microstructures by holographic photopolymerization with a low-power continuous-wave laser of 532 nm.J. Opt. A: Pure Appl. Opt. 8, 1–5, (2006)
L. Z. Cai, C. S. Feng, M. Z. He, X. L. Yang, X. F. Meng, G. Y. Dong and X. Q. YuHolographic design of a two-dimensional photonic crystal of square lattice with pincushion columns and large complete band gapsOPTICS EXPRESS13(11), 4325-4330(2005)
Xian Zhang, Xiaoqiang Yu, Yuming Sun, Yongzhong Wu, Yunguo Feng, Xutang Tao, Minhua Jiang, Synthesis and nonlinear optical properties of a new D--A two-photon photopolymerization initiator.Mater. Lett. 59, 3485–3488, (2005)15
ZHANG Xian, YU Xiao-Qiang, YU Wen-Tao, Zhao Hua-Ping , JIANG Min-Hua, Synthesis and Crystal Structure of E, E-1,4-Bis[4’-(N,N-di-n-butylamino)-styryl]-2,5-Dimenthoxybnezene.Chinese J. Struct. Chem. 24(6), 669－672, (2005)
ZHANG Xian, YU Xiao-Qiang, YU Wen-Tao, He Wei, JIANG Min-Hua, Synthesis and Crystal Structure of E, E-1,4-Bis[4’-(N,N-di-n-butylamino)stilbene.Chinese J. Struct. Chem. 24(8), 875－878, (2005)
張獻，於曉強，於文濤，何畏，陶緒堂，蔣民華，雙光子聚合引發劑DBASDMB的結構何光學性能的研究，功能材料36(10), 1501－1504, (2005)
於曉強，張獻，許貴寶，趙華平，何畏，邵宗書，蔣民華，孫渝明，劉恩泉，利用雙光子聚合技術製備的聚合物型光柵光波導和耦合光柵.高等學校化學學報25(10), 1931－1933, (2004)
Xiaoqiang Yu, Xian Zhang, Kam-sing Wong, Guibao Xu, Xinguang Xu, Yan Ren, Wei He, Xiangang Xu, Zongshu Shao, Xutang Tao, Mihua Jiang, A fabrication of coupling grating in the polymeric waveguide by using two-photon initiated photopolymerization.Mater. Lett. 58, 3879–3883, (2004)
授權專利:
1.於曉強、孫渝明一種單、雙光子半胱氨酸螢光探針及其套用 ZL 2010 1 0558433.0
2.於曉強、馮瑞卿，孫渝明、苗芳一種單、雙光子酸性細胞器螢光探針及其套用ZL201310018340.2
3.於曉強、田明剛、孫渝明、苗芳一種單、雙光子線粒體螢光探針及其套用ZL 201310256318.1
4.於曉強、張革、孫渝明、宋國芬一種用於活細胞中RNA和核仁成像的吲哚吡啶鹽類螢光探針，ZL 201310216501.9
5.於曉強、張若瑤、孫渝明、張革、宋國芬一種用於活細胞中RNA和核仁成像的吡咯吡啶鹽類螢光探針，ZL 201310215970.9
