![徐菲[上海科技大學助理教授]](/img/8/7a6/nBnauM3X4MDM5UzM0YDN0ETN1UTM1QDN5MjM5ADMwAjMwUzL2QzL2MzLt92YucmbvRWdo5Cd0FmLxE2LvoDc0RHa.jpg "徐菲[上海科技大學助理教授]")
個人簡介
2006年獲得中國科技大學生命科學專業學士學位；2011年獲得美國Scripps研究所生物學專業博士學位；2011-2012年上海銳意生物技術有限公司董事（銳意公司創始人之一）。2013年9月加入上海科技大學iHuman研究所任Research Associate Professor，PI。
上海市第十五屆人民代表大會代表。
研究方向
結構生物學
研究內容
1、探索研究疾病信號通路中相關的GPCRs蛋白，2、建立整合性的GPCRs蛋白研究平台套用於研究幹細胞和疾病模型。
代表論文
Liu W, Chun E, Thompson A.A, Chubukov P, Xu F, Katritch V, Han G-W, Roth C.B, Heitman L.H, Ijzerman A.P, Cherezov V, Stevens R.C. “Structural basis for allosteric regulation of GPCRs by sodium ions” Science, 337(6091): 232-236, (2012)
Chun E, Thompson A.A, Liu W, Roth C.B, Griffith M.T., Katritch V, Kunken J, Xu F, Cherezov V, Hanson M.A, Stevens R.C. “Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors” Structure, 20(6): 967-976, (2012)
Tosh D.K, Phan K, Gao Z-G, Gakh A.A, Xu F, Deflorian F, Abagyan R, Stevens R.C, Jacobson K.A, Katritch V. “Optimization of Adenosine 5’ -Carboxamide Derivatives as Adenosine Receptor Agonists Using Structure-Based Ligand Design and Fragment-Based Searching” J Med Chem, 55(9): 4297-4308, (2012)
Deflorian F, Kumar TS, Phan K, Gao Z-G, Xu F, Wu H, Katritch V, Stevens R.C, Jacobson K.A. “Evaluation of Molecular Modeling of Agonist Binding in Light of the Crystallographic Structure of an Agonist-Bound A(2A) Adenosine Receptor” J Med Chem, 55(1): 538-552, (2012)
Xu F, Stevens R.C. “Trapping small caffeine in a large GPCR pocket” Structure, 19(9): 1204-1207, (2011) Invited Review.
Xu F, Wu H, Katritch V, Han G-W, Jacobson K.A, Gao Z-G, Cherezov V, Stevens R.C. “Structure of an agonist-bound human A2A adenosine receptor” Science, 332: 322-327, (2011)
Xu F, Liu W, Hanson M, Stevens R.C, Cherezov V. “Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases” Crystal Growth & Design, 11(4): 1193-1201, (2011)
Guo M, Xu F, Yamada J, Egelhofer T, Gao Y, Hartzog GA, Teng M, Niu L. “Core structure of the yeast Spt4-Spt5 complex: a conserved module for regulation of transcription elongation”Structure, 16:1649-1658, (2008)
