彭玲[法國國家科學研究中心研究員]

彭玲，1966年9月出生。武漢大學珞珈講座教授，法國國家科學研究中心終生研究員。

人物經歷

1986，南京大學化學系，獲學士學位。

1993，瑞士蘇黎世高等理工學院, 獲博士學位。

1993，法國國家科學研究中心助理研究員，法國斯特拉斯堡路易巴斯德大學藥學系。

1997，法國國家科學研究中心研究員，法國斯特拉斯堡路易巴斯德大學藥學系。

1999，法國國家科學研究中心終生研究員，法國馬賽地中海大學化學系。

2000, 教育部長江學者，武漢大學特聘教授。

2003, 武漢大學珞珈講座教授。

研究方向

1.生物小分子探針；2.核酸及藥物的傳輸；3.三唑核苷藥物化學。

主要貢獻

1. Jiehua Zhou, Jiangyu Wu, Nadia Hafdi, Jean-Paul Behr, Patrick Erbacher, Ling Peng, "PAMAM Dendrimers for Efficient siRNA Delivery and Potent Gene Silencing", Chem. Commun. 2006, 2362-2364.

2. Han Chen, Sophie Laurent, Sylvie Bedu, Fabio Ziarelli, Haili Chen, Cheng-Cai Zhang, Ling Peng, "Investigation of the Signalling Role of 2-Oxoglutaric Acid, a Krebs Cycle Intermediate, Using Analogues that Mimic the Ketone and Ketal Forms of 2-Oxoglutaric Acid", Chem. & Biol. 2006, in press.

3. Yi Xia, Zhijin Fan, Jianhua Yao, Quan Liao, Wei Li, Fanqi Qu and Ling Peng, "Discovery of Bitriazolyl Compounds as Novel Antiviral Candidates for Combating the Tobacco Mosaic Virus", Bioorg. Med. Chem. Lett. 2006, 16, 2693-2698.

4. Sophie Laurent, Han Chen, Sylvie Bedu, Fabio Ziarelli, Ling Peng, Cheng-Cai Zhang, "A non-metabolizable analogue of the Krebs-cycle intermediate 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. strain PCC 7120", Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 9907-9912.

5. Jiangyu Wu, Jiehua Zhou, Fanqi Qu, Benhui Bao, Yi Zhang, Ling Peng, "Polycationic dendrimers interact with RNA molecules: Polyamine dendrimers inhibit the catalytic activity of Candida ribozyme", Chem. Comm. 2005, 313-315.

6. Alexandre Specht, Philippe Bernard, Maurice Goeldner, Ling Peng "Mutually Induced Formation of Host-guest Complexes betterave p-Sulfonated Calix[8]arene and Photolabile Cholinergic Ligands", Angew. Chem. Int. Ed. Engl 2002, 41, 4706-4708.

7. Taridaporn Bunyapaiboonsri, Olof Ramström, Sophie Lohmann, Jean-Marie Lehn, Ling Peng, Maurice Goeldner, "Dynamic Deconvolution of a Pre-equilibrated Dynamic Combinatorial Library of Acetylcholinesterase Inhibitors", CHEMBIOCHEM, 2001, 2, 438-444.

8. Ling Peng, Florian Nachon, Jakob Wirz, Maurice Goeldner, "2-Nitrobenzyl Arsonium Compounds Photoreleasing Heavy-Atom Cholinergic Ligands For Time-Resolved Crystallographic Studies on Cholinesterasses ", Angew. Chem. Int. Ed. Engl. 1998, 37, 2691-2693.

9. Ling Peng, Jakob Wirz, Maurice Goeldner, "Synthesis and Characterization of Photolabile Compounds Photoreleasing Nor-acetylcholine in the Microsecond Time Range", Angew. Chem. Int. Ed. Engl. 1997, 36, 398-400.

10. Ling Peng, Israel Silman, Joel Sussman, Maurice Goeldner, "Biochemical Evaluation of Photolabile Precursors of Choline and of Carbamylcholine for Potential Time-Resolved Crystallographic Studies on Cholinesterases", Biochemistry, 1996, 35, 10854-10861.

獲獎記錄

2017年11月21日在巴黎舉行的法國科學院2017年度頒獎典禮，彭玲獲頒“昂里·拉貝博士夫婦獎”。