張新剛[中國科學院上海有機化學研究所研究員]

1994年至1998年就讀於四川大學，獲得學士學位。1998年至2003年就讀於中國科學院上海有機化學研究所（SIOC）獲得博士學位。2003年至2008年在美國伊利諾伊大學香檳分校 (UIUC)從事博士後研究工作，合作導師Wilfred A. van der Donk。2008年至2011年中國科學院上海有機化學研究所（SIOC）副研究員，課題組長。2012年起中國科學院上海有機化學研究所（SIOC）研究員。

論文發表

課題組的代表性論文

Chang Xu, Wen-Hao Guo, Xu He, Ying-Long Guo, Xue-Ying Zhang, and Xingang Zhang* “Difluoro-methylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel”Nat. Commun.,2018,9, 1170-1179.

Zhang Feng, Qiao-Qiao Min, Xia-Ping Fu, Lun An and Xingang Zhang,* “Chlorodifluoromethane-Triggered Formation of Difluoromethylated Arenes Catalysed by Palladium”,Nat. Chem.2017,9, 918-923.(This paper was highlighted byChemical & Engineering News2017,95, 7; ACS Molecule of the Week, 2017, June 19)

Ji-Wei Gu, Qiao-Qiao Min, Ling-Chao Yu, and Xingang Zhang,* “Tandem Difluoroalkylation-Arylation of Enamides Catalyzed by Nickel”Angew. Chem. Int. Ed.2016,55, 12270-12274.

Yu-Lan Xiao,Wen-Hao Guo, Guo-Zhen He,Qiang Panand Xingang Zhang*. "Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes"Angew. Chem. Int. Ed.2014,53，9909-9913(This paper was highlighted byChemical & Engineering News2014,92, 25).

Zhang Feng, Qiao-Qiao Min, Yu-Lan Xiao, Bo Zhang and Xingang Zhang*. "Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives"Angew. Chem. Int. Ed.2014,53, 1669-1673(This paper was highlighted byChemical & Engineering News2014,92, 25).

Xingang Zhang*, Shilu Fan, Chun-Yang He, Xiaolong Wan, Qiao-Qiao Min, Jie Yang and Zhong-Xing Jiang, “Pd(OAc)Catalyzed Olefination of Highly Electron-deficient Perfluoroarenes”J. Am. Chem. Soc.2010,132, 4506-4507.

1.

Chang Xu, Wen-Hao Guo, Xu He, Ying-Long Guo, Xue-Ying Zhang, and Xingang Zhang* “Difluoro-methylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel”Nat. Commun.,2018,9, 1170-1179.

2.

Zhang Feng, Qiao-Qiao Min, Xia-Ping Fu, Lun An and Xingang Zhang,* “Chlorodifluoromethane-Triggered Formation of Difluoromethylated Arenes Catalysed by Palladium”,Nat. Chem.2017,9, 918-923.(This paper was highlighted byChemical & Engineering News2017,95, 7; ACS Molecule of the Week, 2017, June 19)

3.

Ji-Wei Gu, Qiao-Qiao Min, Ling-Chao Yu, and Xingang Zhang,* “Tandem Difluoroalkylation-Arylation of Enamides Catalyzed by Nickel”Angew. Chem. Int. Ed.2016,55, 12270-12274.

4.

Yu-Lan Xiao,Wen-Hao Guo, Guo-Zhen He,Qiang Panand Xingang Zhang*. "Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes"Angew. Chem. Int. Ed.2014,53，9909-9913(This paper was highlighted byChemical & Engineering News2014,92, 25).

5.

Zhang Feng, Qiao-Qiao Min, Yu-Lan Xiao, Bo Zhang and Xingang Zhang*. "Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives"Angew. Chem. Int. Ed.2014,53, 1669-1673(This paper was highlighted byChemical & Engineering News2014,92, 25).

6.

Xingang Zhang*, Shilu Fan, Chun-Yang He, Xiaolong Wan, Qiao-Qiao Min, Jie Yang and Zhong-Xing Jiang, “Pd(OAc)Catalyzed Olefination of Highly Electron-deficient Perfluoroarenes”J. Am. Chem. Soc.2010,132, 4506-4507.

獲獎及榮譽

2017 年 科技部萬人計畫

2016 年 科技部中青年科技創新領軍人才

2015年英國皇家化學會氟化學獎

2015 年 英國皇家化學會氟化學獎(RSC Fluorine Chemistry Prize)

2015 年 第五屆中國化學會—英國皇家化學會青年化學家獎

2014 年 國家“傑出青年科學基金”

2009 年 上海市啟明星計畫

研究方向

課題組主要集中在三個研究方向：

1）金屬有機氟化學 以過渡金屬催化為手段，研究廉價易得的含氟工業原料和工業廢棄物的高效轉化，使之具有工業套用前景，建立高效廉價金屬催化體系，發展高效溫和的氟化新策略、新反應、新方法以及相關理論；

2）化學生物學相關研究 套用化學生物學手段研究和發現新的含氟生物活性分子，探索氟原子對相關生物活性分子影響的內在本質規律；利用氟原子的特性發展對多肽、蛋白，核酸進行選擇性修飾的方法，並進一步套用到化學生物學中；

3）能源相關含氟材料的研究 基於所發展方法研究含氟化合物在光伏和電池材料方面的套用。