![孫遜[四川大學華西藥學院教授，博士生導師]](/img/3/70f/nBnauM3X0QDO4czMwQzMwUzN1UTM1QDN5MjM5ADMwAjMwUzL0MzLxczLt92YucmbvRWdo5Cd0FmL0E2LvoDc0RHa.jpg "孫遜[四川大學華西藥學院教授，博士生導師]")
簡歷
1991～1996 華西醫科大學藥學院 獲理學學士學位
1996～2000 廣州珠江醫院 從事臨床藥學工作
2000～2005 四川大學華西藥學院 獲藥劑學博士學位
2005～ 四川大學華西藥學院任講師、副教授
2005～2007 美國賓夕法尼亞大學醫學院博士後, 師從世界著名基因治療學家James Wilson教授
2007～2008 美國密西根大學藥學院博士後, 師從Kyung Dull Lee 教授。
主要科研和教學情況
1. 基於載體構-效關係設計的多功能高效肺靶向siRNA傳遞系統研究(國家自然科學基金，項目編號：309。73657，起止日期2010.1-2012.12, 負責人)
2. Hyaluronan-based injectable material for tissue engineering（歐盟第七框架項目，項目編號：PIRSES-GA-2008-230791,起止日期2010.1-2012.12, 負責人)
3. 呼吸道黏膜上皮細胞靶向基因傳遞系統研究 (國家自然科學基金，項目編號：3060。0786，起止日期2007.1-2009.12, 負責人)
4. 馬來酸氟吡啶緩釋片、緩釋膠囊的研製（企業合作項目，項目編號：09H0114-2,負責人）
5. IL-12基因納米脂質體注射劑的研究 (四川省重點科技攻關項目，項目編號：05SG022-019-2,起止日期2006.1-2008.12, 負責人)
6. 靶向釋藥系統與新製劑技術平台的建設（國家科技重大專項項目，項目編號：2009ZX09310-002,主研）
7. 藥物及治療基因納米粒製劑的研究與開發（國家高技術研究發展863計畫課題，項目編號：2003AA217010,主研）
8. 血管內注射藥用高分子材料PELGE及其肝靶向納米粒研製（國家自然科學基金重點項目，項目編號：3043。0770,主研）
獲獎情況
1.“治療基因靶向傳遞系統的研究”2006年四川省科技進步三等獎 （第2完成人）
2. 2008年度“全國百篇優秀博士論文”提名獎
3. 2009年第四屆國際藥物製劑論壇優秀青年報告獎
4. 2005年和2009年分別獲得日本永井基金會Travel Grant
代表論著
1. Xun Sun, Chet Provoda, Kyung-Dall Lee. Enhanced in vivo gene expression mediated by Listeriolysin O incorporated anionic LPDII: Its utility in Cytotoxic T lymphocyte-inducing DNA Vaccine. Journal of Controlled Release. IF=5.949， 2010；148（2）：219-225.
2. Xun Sun, You Lu, Larry Bish, Roberto Calcedo, James M. Wilson, Guangping Gao*. Molecular analysis of vector genome strucures following liver transduction by conventional and self-complementary AAV serotype vectors in murine and nonhuman primate models. Human Gene Therapy. IF=4.202. 2010;21(6)1-12.
3. Jianfeng Han, Dong Zhao, Zhirong Zhong, , Zhirong Zhang, Tao Gong and Xun Sun*. Combination of adenovirus and cross-linked low molecular weight PEI improves efficiency of gene transduction. Nanotechnology, IF=3.137. 2010;21(10):105106.
4. Zhi-Rong ZHONG, San-Jun SHI, Jian-Feng HAN, Zhi-Rong ZHANG, Xun SUN*. Anionic Liposomes Increase the Efficiency of Adenovirus-mediated Gene Transfer to Coxsackie-Adenovirus Receptor Deficient Cells, Mol. Pharm. 2010;7(1)105-115. IF=5.408.
5. Jiao Lu, Di Zhu, Zhi-rong Zhang, Li Hai, Yong Wu, Xun Sun*. Novel synthetic LPDs consisting of different cholesterol derivatives for gene transfer into hepatocytes. Journal of Drug Targeting. 2010 Aug;18(7):520-35. IF=2.885.
6. Lili He, Likai Yang, Zhi-rong Zhang, Tao Gong, Li Deng, Zhongwei Gu, Xun Sun*. In vitro evaluation of the genotoxicity of a family of novel MeO-PEG-poly (D,L- lactic-co-glycolic acid)-PEG-OMe Triblock Copolymer nanoparticles. Nanotechnology, IF=3.137. 2009;20(45):455102.
7. Qing-Hua Zhou, Xun Sun, Lin-Yuan Zeng, Jie Liu, Zhi-Rong Zhang*, A Randomized Multi- center Phase II Clinical trial of Mitoxantrone- loaded Polybutylcyanacrylate nanoparticles in the Treatment of 108 patients with inoperable hepatocellular carcinoma. Nanomedicines-UK, 2009：5（4）419-423. IF=5.44（共同第一作者）.
8. Xun SUN，Hong-Wei ZHANG，Zhi-Rong ZHANG. Growth Inhibition of the Pulmonary Metastatic Tumors by Systemic Delivery of p27kip1 Gene Using Lyophilized Lipid-Polycation-DNA complexes (LPD). Journal of Gene Medicine, 2009;11:535-544. IF=3.141.
9. Zhi-xiang Yuan, Xun Sun*, Tao Gong, Hong Ding, Fu Chen, Zhi-rong Zhang*. Randomly 50% N-acetylated low molecular weight chitosan as a novel renal targeting carrier. Journal of Drug Targeting.2007,15(4):269-278. SCI.
10. Guang-Ping Gao, You Lu, Xun Sun, Julie Johnston, Roberto Calcedo, Rebecca Grant and James M. Wilson. High level transgene expression in nonhuman primate liver with novel AAV serotypes containing self-complementary genomes. Journal of Virology, 2006;80(12):6192-6194. SCI（共同第一作者）.
11. Xun Sun, Li Hai, Yong Wu, Zhi-Rong Zhang. Targeted gene delivery to Hepatoma cells using galactosylated liposome-polycation-DNA complexes (LPD). Journal of Drug Targeting. 2005;13(2):121-128. SCI.
12. Xun Sun, You-Rong Duan, Oin He, Jiao Lu, Zhi-Rong Zhang. PELGE nanoparticles as new carriers for the delivery of plasmid DNA. Chem.Pharm.Bull. 2005; 53 (6):599-603. SCI.
13. Xun Sun, Fang Wu, Wei Lu, Zhi-Rong Zhang. Sustained-release hydroxylcamptothecin polybutylcyanoacrylate nanoparticles as a liver targeting drug delivery system. Pharmazie, 2004.59(10): 791-794. SCI.
14. Xun Sun，Zhi-Rong Zhang. Optimizing the novel formulation of liposome- polycation-DNA complexes (LPD) by central composite design. Archives of Pharmacal Research 2004; 27(7): 797-805. SCI.
15. Xun SUN，Hong-Wei ZHANG，Zhi-Rong ZHANG. Transfection efficiency of pORF lacZ plasmid lipopolyplexes to hepatocyte and hepatoma cells. World Journal of Gastroenterology. 2004，10(4):531-534.
參編書目
1. 國家基本醫療保險藥品使用手冊。北京：中國勞動社會保障出版社，2001.3 編委。
2. 靶向治療分子基礎與靶向藥物設計。北京：科學出版社。2005.10 編委
