孫寶林,教授,博士生導師。“中科院百人計畫”入選者。1986年牡丹江師範學院學士;1989年中科院遺傳所碩士;1999年密西根州立大學博士。
研究興趣
重要致病細菌群體感應與生物膜發育及致病機理;細菌非編碼小RNA調控的細胞行為。詳情請見實驗室主頁sunlab點ustc點edu點cn主要在研課題
1.中國科學院“百人計畫”專項,2004.01–2007.12,資助金額:270萬。2.國家“十一五”科技重大專項“愛滋病和病毒性肝炎等重大傳染病防治”子課題“結核病靶標研究”,2008.10–2011.05,資助金額:315萬。
3.中國科學院知識創新工程“結核分枝桿菌致病機制、快速診斷和新型藥物研究”,2009.6–2011.05,資助金額:60萬。
4.國家自然科學基金“金黃色葡萄球菌非編碼小RNA的功能解析”,2010.01–2012.12,資助金額:40萬。
5.國家自然科學基金“金黃色葡萄球菌KdpDE二元信號轉導系統對致病性的調控研究”,2011.01–2013.12,資助金額:34萬。
近期論文
Xiong,M.,Y.Bao,X.Yang,Y.Wang,B.Sun,andJ.Wang(2012).Lipase-sensitivepolymerictriple-layerednanogelfor"on-demand"drugdelivery.J.Am.Chem.Soc.134:4355-4362.Xue,T.,Y.You,F.Shang,andB.Sun(2012).RotandAgrsystemmodulatefibrinogen-bindingabilitymainlybyregulatingclfBexpressioninStaphylococcusaureusNCTC8325.Med.Microbiol.Immunol.201:81-92.
Xue,T.,Y.You,D.Hong,H.Sun,andB.Sun(2011).TheStaphylococcusaureusKdpDEtwo-componentsystemcouplesextracellularKsensingandAgrsignalingtoinfectionprogramming.Infect.Immun.79:2154-2167.
Zhao,L.,T.Xue,F.Shang,H.Sun,andB.Sun(2010).StaphylococcusaureusAI-2quorumsensingassociateswiththeKdpDEtwo-componentsystemtoregulatecapsularpolysaccharidesynthesisandvirulence.Infect.Immun.78:3506-3515.
Tao,L.,X.Wu,andB.Sun(2010).AlternativesigmafactorσmodulatesprophageintegrationandexcisioninStaphylococcusaureus.PLoSPathog.6:e1000888.
Shang,F.,T.Xue,H.Sun,L.Xing,S.Zhang,Z.Yang,L.Zhang,andB.Sun(2009).TheStaphylococcusaureusGGDEFdomain-containingprotein,GdpS,influencesproteinAgeneexpressioninacyclicdiguanylicacid-independentmanner.Infect.Immun.77:2849-2856.
Huang,J.,B.Sun,andX.Zhang(2010).Shewanellaxiamenensissp.nov.,isolatedfromcoastalseasediment.Int.J.Syst.Evol.Microbiol.60:1585-1589.
Huang,J.,B.Sun,andX.Zhang(2010).ElectricitygenerationathighionicstrengthinmicrobialfuelcellbyanewlyisolatedShewanellamarisflaviEP1.Appl.Microbiol.Biotechnol.85:1141-1149.
Xue,T.,L.Zhao,H.Sun,X.Zhou,andB.Sun(2009).LsrRbinding-siterecognitionandregulatorycharacteristicsinEscherichiacoliAI-2quorumsensing.CellRes.19:1258-1268.
Wu,C.andB.Sun(2009).IdentificationofnovelesterasefrommetagenomiclibraryofYangtzeRiver.J.Microbiol.Biotechnol.19:187-193.
Chu,X.,H.He,C.Guo,andB.Sun(2008).IdentificationoftwonovelesterasesfromamarinemetagenomiclibraryderivedfromSouthChinaSea.Appl.Microbiol.Biotechnol.80:615-625.
Zhou,X.,X.Meng,andB.Sun(2008).AnEALdomainproteinandcyclicAMPcontributetotheinteractionbetweenthetwoquorumsensingsystemsinEscherichiacoli.CellRes.18:937-948.
Ju,X.,L.Zhao,andB.Sun(2007).Nitrogenfixationbyreductivelydechlorinatingbacteria.Environ.Microbiol.9:1078-1083.
Sun,B.,B.M.Griffin,H.L.Ayala-del-Río,S.A.Hashsham,andJ.M.Tiedje(2002).Microbialdehalorespirationwith1,1,1-trichloroethane.Science298:1023-1025.
Sun,B.,J.R.Cole,andJ.M.Tiedje(2001).Desulfomonilelimimarissp.nov.,ananaerobicdehalogenatingbacteriumfrommarinesediments.Int.J.Syst.Evol.Microbiol.51:365-371.
Sun,B.,J.R.Cole,R.A.Sanford,andJ.M.Tiedje(2000).IsolationandcharacterizationofDesulfovibriodechloracetivoranssp.nov.,amarinedechlorinatingbacteriumgrowingbycouplingtheoxidationofacetatetothereductivedechlorinationof2-chlorophenol.Appl.Environ.Microbiol.66:2408-2413.