主要成就
在他的領導下,已經發現了2個重要的微生物信號調控小分子(ComX pheromone,hormone alpha1)和2個重要的植物細胞信號調控小分子(PSK、CLV3 peptide),對PSK peptide的生物合成途徑及其功能進行了長期、深入的研究,發現PSK及CLV3 peptide的受體。發表了100多篇高水平的研究論文,其中Science 6篇,Nature Chemical Biology 2篇,PNAS 3篇。
代表性論文
1. An LRR receptor kinase involved in perception of a peptide plant hormone, phytosulfokine. Y. Matsubayashi, M. Ogawa, A. Morita and Y. Sakagami Science, 296,1470-1472 (2002)
2. Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX. M. Okada, I. Sato, S-J. Cho, H. Iwata, T. Nishio, D. Dabnau, and Y. Sakagami Nature Chemical Biology, 1, 23-24 (2005)
3. Characterization of a Phytophthora mating hormone. J. Qi, T. Asano, M. Jinno, K. Matsui, K. Atsumi, Y. Sakagami and M. Ojika Science, 309, 1828 -1828 (2005)
4. A plant peptide encoded by CLV3 identified by in situ MALDI-TOF MS analysis. T. Kondo, S. Sawa, A. Kinoshita, S. Mizuno, T. Kakimoto, H. Fukuda and Y. Sakagami Science, 313, 845-848 (2006)
5. Arabidopsis CLV3 Peptide Directly Binds CLV1 Ectodomain. M. Ogawa, H. Shinohara, Y. Sakagami and Y. Matsubayashi Science, 319, 294-294(2008)
6. Synthesis and absolute configuration of hormone alpha1. A. Yajima, Y. Qin, X. Zhou, N. Kawanishi, X. Xiao, J. Wang, D. Zhang, Y. Wu, T. Nukada, G. Yabuta, J. Qi, T. Asano and Youji Sakagami Nature Chemical Biology, 2008, 4, 235-237.