![周翔[武漢大學化學與分子科學學院院長]](/img/9/b84/nBnauM3X3EzNxQTO1gzM5EDN0UTMyITNykTO0EDMwAjMwUzL4MzLzUzLt92YucmbvRWdo5Cd0FmLxE2LvoDc0RHa.jpg "周翔[武漢大學化學與分子科學學院院長]")
人物經歷
1982.9-1989.7 學士，碩士，武漢大學化學系。
1989.7-1992.12 助教，講師，武漢大學化學系。
1992.12-1995.5 博士，香港中文大學化學系。
1996.10-1998.10 博士後，美國Department of Chemistry, University of Virginia,Professor Dr. S. M. Hecht 課題組。
1998.11-2001.5 博士後，美國Department of Chemistry and Biochemistry, University ofMaryland, College Park, Professor Dr. S. E. Rokita 課題組。
2001.5--至今 教授，博導, 武漢大學化學與分子科學學院。
2009--至今 教育部長江學者特聘教授。
2011年973首席科學家。
研究方向
生物有機化學、藥物化學和化學生物學。
![周翔[武漢大學化學與分子科學學院院長]](/img/e/0c8/wZwpmLyUDN4cDOwkzMxMDN0UTMyITNykTO0EDMwAjMwUzL5MzLwQzLt92YucmbvRWdo5Cd0FmLzE2LvoDc0RHa.jpg)
周翔[武漢大學化學與分子科學學院院長]主講課程
主講本科生課程：《生物化學》
主講研究生課程：《生物有機化學》
主要貢獻
1.主持國家自然科學基金重大研究計畫重點項目：《化學小分子探針對染色體端粒DNA結構、生物學活性及相關信號轉導的干預和影響》（90813031, 2009年）
2.主持國家自然科學基金傑出青年基金：《生物有機化學》（20425206， 2005年）
3. 主持國家自然科學基金面上項目：《可誘導核酸交聯劑的設計、合成及生物活性研究》(21072155, 2011年)，《以端粒酶為靶標的抗腫瘤候選藥物設計合成及活性研究》（30973605, 2010年），
4.主持高等學校科技創新工程重大項目培育資金項目：《以核酸為靶目標的抗腫瘤藥物分子的設計、合成及其活性研究》
5.主持教育部《跨世紀優秀人才培養計畫》基金 。
學術成果
1. Wang, S., Long, Y., Wang, J., Ge, Y., Guo, P., Liu, Y., Tian, T.* and Zhou, X*. Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: The effects on the BZ transition. J. Am. Chem. Soc. 2014. 136.56-59.
2. Wang, T., Hong, T., Tang, T., Zhai, Q., Xing, X., Mao, W., Zheng, X., Xu, L., Wu,J.,Weng,X.,Wang,S.,Tian,T.,Yuan,B.,Huang,B.,Zhuang,L.and Zhou, X.*Application of N-Halogeno-N-sodiobenzenesulfonamide Reagents to the Selective Detection of 5-Methylcytosine in DNA Sequences. J. Am. Chem. Soc., 2013, 135, 1240-1243.
3. Yuan, L., Tian, T., Chen, Y., Yan, S., Xing, X., Zhang, Z., Zhai, Q., Xu, L., Wang, S., Weng, X. and Zhou, X*. Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy. Sci Rep., 2013,3: 1811.
4. Hu, J., Xing, X., Xu, X., Wu, F., Guo, P., Yan, S., Xu, Z., Xu, J., Weng, X. and Zhou, X.*. Selective Chemical Labelling of 5‐Formylcytosine in DNA by Fluorescent Dyes. Chem. Eur. J., 2013,19, 5836-5840.
5. Wu, Z., Tian, T., Yu, J., Weng, X., Liu, Y. and Zhou,X.*Formation of Sequence‐Independent Z‐DNA Induced by a Ruthenium Complex at Low Salt Concentrations. Angew. Chem. Int. Ed., 2011,123, 12168-12173.
6. Bai, M., Huang, J., Zheng, X., Song, Z., Tang, M., Mao, W., Yuan, L., Wu, J., Weng, X. and Zhou, X.*Highly selective suppression of melanoma cells by inducible DNA cross-linking agents: bis (catechol) derivatives. J. Am. Chem. Soc., 2010, 132, 15321-15327.
7. X. L. Wang, J. Huang, Y. Y. Zhou, S. Y. Yan, X. C. Weng, X. J. Wu, M. G. Deng, X. Zhou*, The Switching of G-quadruplex Structure by Photoregulation. Angew. Chem. Int. Ed., 2010, 49, 5305. ( Hot Paper)
8. M. G. Deng, D. Zhang, Y. Y. Zhou, X. Zhou*, Highly effective colorimetric and visual detection of nucleic acids using an asymmetrically split peroxidase DNAzyme. J. Am. Chem. Soc., 2008, 130, 13095.
9. X. C. Weng, L. G. Ren, L. W. Weng, J. Huang, S. G. Zhu, X. Zhou*, L. H. Weng, Synthesis and biological studies of inducible DNA cross-linking agents. Angew. Chem. Int. Ed., 2007, 46, 8020.
10. P. Wang, R. P. Liu, X. J. Wu, H. J. Ma, X. P. Cao, P. Zhou, J. Y. Zhang, X. C. Weng, X. L. Zhang, J. Qi, X. Zhou*, L. H. Weng, A potent, water-soluble and photoinducible DNA cross-linking agent. J. Am. Chem. Soc., 2003, 125, 1116. (Highlighted by Heart Cut, March, July, 2003)
科研論文
1.Ping Wang, Renpeng Liu, Xiaojun Wu, Hongjuan Ma, Xiaoping Cao, Ping Zhou, Jiangye Zhang, Xiaocheng Weng, Xiao-Lian, Zhang, Jun Qi, Xiang Zhou*, Linhong Weng, 2003, “A Potent, Water-soluble and Photoinducible DNA Cross-linking Agent”, J. Am. Chem. Soc., 125, 1116-1117
2. Jiangye Zhang, Xiaojun Wu, Xiaoping Cao, Fang Yang, Jiangfeng Wang, Xiang Zhou* and Xiao-Lian Zhang, 2003, “Synthesis and anti bacterial study of 10, 15,20-triphenyl-5- {4-hydroxy-3-(trimethyl ammonium) methyl}phenylporphyrin as models for combination of porphyrin and alkylating agent”, Bioorg. Med. Chem. Lett., 13, 1097.
3. Anil T. Abraham, Xiang Zhou, and Sidney M. Hecht, “Metallo bleomycin- mediated Cleavage of DNA Not Involving a Threading-intercalation Mechanism”, J. Am Chem. Soc., 2001, 123 (22), 5167.
4. Xiang Zhou, Jason Shearer，Steven E. Rokita, “A Ni(salen)-biotin Conjugate for Rapid Isolation of Accessible DNA”, J. Am. Chem. Soc., 2000, 122, 9046.
5. X. Zhou, Man Kin Tse, De-Dong Wu, T. C. W. Mak, K. S. Chan, “Diverse Reactivity of Rhodium b-(Tetraphenyl)tetraphenyl Porphyin Chloride with Benzonitrile: Formation of Rh Porphyrin Aren and Imineo Complexs”, J. Organomet. Chem., 2000, 598, 80.
6. Xiangyang Wang, Xiang Zhou and Sidney M. Hecht, “On the Role of 20-hydroxyl group in Camptothecin Binding by the Topoisomerase I-DNA Binding Complex”, Biochemistry, 1999, 38, 4374.
7. Anil T. Abraham, Xiang Zhou, and Sidney M. Hecht, “DNA Cleavage by Fe(II).Bleomycin Conjugated to a Solid Support”, J. Am Chem. Soc., 1999, 121, 1982.
8. X. Zhou, R. –J. Wang, F. Xue, T. C. W. Mak, K. S. Chan, “Novel Rhodium porphyrin Complexes: Intermolecular Acyivation of Arene Carbon- Hydrogen Bond and Formation of a Nitrile-Bridged Coordination Polymer”, J. Organomet. Chem., 1999, 580, 22
9. Kiyoaki Katano, Haoyun An, Yoshiaki Aoyagi, Mark, Overhand, Steven J. Sucheck, William C. Stevens, Jr., Cynthia D. Hess, Xiang Zhou and Sidney M. Hecht, “ Total Synthesis of Bleomycin Group Antibiotics. Total Synthesis of Bleomycin Demethyl A2”, J. Am. Chem. Soc., 1998, 118, 11284
10. Xiang Zhou, Qi Li, Thomas C. W. Mak and Kin Shing Chan, “Synthesis of rhodium porphyrin aryls via intermolecular aren carbon-hydrogen bond activation”, Inorg. Chim. Acta, 1998, 270, 551
11. Xiang Zhou, Kin Shing Chan, “Synthesis of b-Linked Diporphyrins and their Homo-and Hetero-biometallic complexes”, J. Org. Chem., 1998, 63, 99
學術兼職
1．國務院學位委員會第六屆學科評議化學組成員
2．國家自然科學基金委第十一、十二屆化學科學部專家評審組成員
3．教育部留學回國人員科研啟動基金評審專家
4．第三屆湖北省科學技術獎評審委員會委員
5. 教育部生物有機與分子工程重點實驗室學術委員會委員
6. 湖北省化學化工學會副理事長
7. 高等學校化學教育研究中心第四屆學術委員會委員
8. 中國化學會化學生物學專業委員會委員
獲獎記錄
教育部《跨世紀優秀人才培養計畫》
1．2010年湖北省自然科學一等獎
2. 2010年藥明康德生命化學研究獎二等獎
3．2009年教育部“長江學者特聘教授”
4．2004年獲得國家傑出青年基金
5．2002年教育部跨世紀優秀人才培養計畫
6．2004年湖北省第十屆自然科學優秀學術論文特等獎
