劉輝宇，醫學博士 劉輝宇-專業：分子生物學，分子信號傳達。 劉輝宇-職稱：美國HAMNER研究院研究員 劉輝宇-單位及地址： Hamner研究院生物醫學學組 美國北卡三角研究園 劉輝宇-教育與工作經歷： 1979~1984 湖南南華大學醫學院醫學學士(衡陽醫學院醫療系) 1984~1986 北京302醫院肝炎科醫師 1986~1989 軍醫進修學院傳染病學系醫學碩士 1989~1993 北京302醫院肝炎科主治醫師 1993~1995 日本群馬大學預防醫學和病毒學系研究助手 1995~1999 日本群馬大學預防醫學和病毒學系醫學博士(醫學生物化學專業) 1999~2000 美國堪薩斯大學藥理系(Lawrence,KS,USA)博士後(G蛋白信號傳達) 2000~2002 加拿大西安大略大學生物化學系博士後 (生物化學專業，神經細胞發育的基因調控與信號傳達) 2002~2005 加拿大Robarts研究所細胞生物學組CIHR研究員(CIHRResearchFellow) 2005~2006 加拿大多倫多大學St.Michael’s醫院高級研究員(SeniorResearchAssociate) 2006~2007 美國HAMNER研究院研究員(ResearchScientist) 2007~現在 美國HAMNER研究院研究員(ResearchInvestigator) 劉輝宇-職業學會： 1986~1993 中華醫學會傳染病學分會會員 1994~2000 日本愛滋病研究學會會員 1998~2000 日本神經病毒學研究學會會員 2003~現在 加拿大生物化學，分子和細胞生物學學會會員 2003~現在 美國生物化學和分子生物學學會會員 2003~現在 美國實驗生物學學會會員 劉輝宇-榮譽和獎勵: 1987年 軍隊科技進步獎二等獎(證書號：?) 1993年 軍隊科技進步獎三等獎(證書號：93-3-055-3) 1995年 軍隊科技進步獎二等獎(證書號：95-2-171-4) 1993-1999年 日本文部省政府學者獎學金 劉輝宇-社會活動： 編委雜誌 WorldJournalofBiologicalChemistry 審稿雜誌 BritishJournalofPharmacology; FEBSLetter; Nutrition,Metabolism&CardiovascularDiseases;
基金評審CanadaFoundationforInnovation(CFI)theLeadersOpportunityFund(LOF). 劉輝宇-論文： 學位論文: 1.博士學位論文(英文) 題目：CD4-dependentandCD4-independentutilizationofGprotein-couplereceptorsbyhumanimmunodeficiencyvirustype2andsimianimmunodeficiencyvirusstrains 2.碩士學位論文(中文): 題目：慢性病毒性肝炎及肝炎後肝硬變的胰島素拮抗激素和紅細胞胰島素受體特徵 劉輝宇-英文論著： 1. ShimizuN,KobayashiM,LiuHY,KidoH,HoshinoH(1995)DetectionoftryptaseTL2andCD26antigeninbrain-derivedcellsnon-permissivetoT-cellline-tropichumanimmunodeficiencyvirustype1.FEBSLetter358:48-52.(影響因子,3.264) 2. SodaY,ShimizuN,JinnoA,LiuHY,KanbeK,KitamuraT,andHoshinoH(1999)EstablishmentofanewsystemfordeterminationofcoreceptorusagesofHIVbasedonthehumangliomaNP-2cellline.BiochemicalandBiophysicalResearchCommunications258(2):313-321.(影響因子,2.823) 3.ShimizuN,SodaY,KanbeK,LiuHY,JinnoA,KitamuraT,andHoshinoH(1999)AnorphanGproteincoupledreceptor,GPR1,actsasacoreceptortoallowreplicationofhumanimmunodeficiencyvirustypes1and2inbrain-derivedcells.JournalofVirology73(6):5231-5239.(影響因子,5.308) 4. WenzelSeifertK,HurtC,LiuHY,andSeifertR.(1999)QuantitativeanalysisofformaylpeptidereceptorcouplingtoGiα1,Giα2,andGiα3.JournalofBiologicalChemistry274(47):33259-33266.(影響因子,5.520) 5.ShimizuN,SodaY,KanbeK,LiuHY,mukaiR,KitamuraT,HoshinoH(2000)AputativeGproteincoupledreceptor,RDC1,isanovelcoreceptorforhumanandsimianimmunodeficiencyviruses.JournalofVirolology74(2):619-626.(影響因子,5.308) 6.ZouMX*,LiuHY*(*equalcontributors),HaraguchiY,SodaY,TatemotoK,HoshinoH(2000)Apelinpeptidesblocktheentryofhumanimmunodeficiencyvirus(HIV).FEBSLetter473(1):15-18.(影響因子,3.264) 7.TokizawaS,ShimizuN,LiuHY,DeyuF,HaraguchiY,OiteT,HoshinoH(2000)InfectionofmesangialcellswithHIVandSIV:identificationofGPR1asacoreceptor.KidneyInternational58(2):607-617.(影響因子,6.418) 8. LiuHY,SodaY,ShimizuN,HaraguchiY,JinnoA,TakeuchiY,HoshinoH.(2000)CD4-DependentandCD4-independentutilizationofcoreceptorsbyhumanimmunodeficiencyvirusestype2andsimianimmunodeficiencyviruses.Virology278(1):276-288.(影響因子,3.278) 9. LiuHY*(*equalcontributors),Wenzel-SeifertK*,andSeifertR.(2001)TheolfactoryG-proteinGαolfpossessesalowerGDP-affinityanddeactivatesmorerapidlythanGSαshort:Consequencesforreceptor-couplingandadenylylcyclaseactivation.JournalofNeurochemistry78:325-338.(影響因子,4.553) 10. Wenzel-SeifertK,LiuHY,andSeifertR.(2002)Similaritiesanddifferencesinthecouplingofhumanβ1-andβ2-adrenoceptorstoGsαsplicevariants.BiochemicalPharmacology64:9-20.(影響因子,4.838) 11. LiuHYandSeifertR.(2002)DistinctinteractionsofGSα-long,GSα-short,andGαolfwithGTP,ITP,andXTP.BiochemicalPharmacology64:583-593.(影響因子,4.838) 12. GilleA,LiuHY,sprangSRandSeifertR.(2002)DistinctInteractionsofGTP,UTP,andCTPwithGsProteins.JournalofBiologicalChemistry277:34434-34442.(影響因子,5.520) 13. LiuHYandMeakinSO.(2002)ShcBandShcCactivationbytheTrkfamilyofreceptortyrosinekinases.JournalofBiologicalChemistry277:26046-26056.(影響因子,5.520) 14. LiuHY,MacDonadJIS,LiC,andMeakinSO.(2005)HumanTid1associateswiththeTrkfamilyofreceptortyrosinekinasesandfacilitatesneuriteoutgrowthinnnr5-TrkAcells.JournalofBiologicalChemistry280(20):19461-19471.(影響因子,5.520) 15. CollinsQF,XiongY,LupoEG,LiuHY,andCaoW.(2006)p38Mitogen-activatedproteinkinasemediatesfreefattyacidinducedgluconeogenesisinhepatocytes.JournalofBiologicalChemistry2006;281(34):24336-24344.(影響因子,5.520) 16.XiongY,CollinsQF,AnJ,LupoE,LiuHY,LiuD,RobidouxJ,LiuZ,andCaoW.(2007)p38mitogen-activatedproteinkinaseplaysaninhibitoryroleinhepaticlipogenesis.JournalofBiologicalChemistry282(7):4975-4982.(影響因子,5.520) 17. LiuHY,CollinsQF,XiongY,MoukdarF,LupoEG,LiuZ,andCaoW.(2007)Prolongedtreatmentofprimaryhepatocyteswitholeateinducesinsulinresistancethroughp38mitogen-activatedproteinkinase.JournalofBiologicalChemistry282(19):14205-14212.(影響因子,5.520) 18. CollinsQF,XiongY,LiuHY,PiJ,QuonMJandCaoW.(2007).Epigallocatechin-3-gallate(ecgc),agreenteapolyphenol,suppresseshepaticgluconeogenesisthrough5’-AMP-activatedproteinkinase(AMPK).JournalofBiologicalChemistry282(41):30143-30149.(影響因子,5.520) 19.CaoWH,XiongY,CollinsQF,LiuHY.(2007)p38mitogen-activatedproteinkinaseplaysacriticalroleinthecontrolofenergymetabolismanddevelopmentofcardiovasculardiseases(Englishreview).ZhongNanDaXueXueBaoYiXueBan(JournalofCentralSouthUniversity-Medicalsciences)32(1):1-14.(影響因子,0) 20. KimJH,KimJE,LiuHY,CaoW,andChenJ.(2008)Regulationofinterleukin-6-inducedhepaticinsulinresistancebymammaliantargetofrapamycinthroughtheSTAT3-SOCS3pathway.JournalofBiologicalChemistry283(2):708-715.(影響因子,5.520) 21. SyedaF*,LiuHY*(*equalcontributors),TullisE,LiuM,SlutskyAS,andZhangH.(2008)DifferentialsignalingmechanismsofHNP-inducedIL-8productioninhumanlungepithelialcellsandmonocytes.JournalofCellPhysiology214(3):820-827.(影響因子,4.313) 22. LiuHY,CollinsQF,MoukdarF,ZhuoD,HanJ,HongT,CollinsSandCaoW.(2008)Suppressionofhepaticglucoseproductionbyhumanneutrophilalpha-defensinsthroughasignalingpathwaydistinctfrominsulin.JournalofBiologicalChemistry283(18):12056-12063.(影響因子,5.520) 23. LiuHY*(*correspondenceauthors),WenGB,HanJ,HongT,ZhuoD,LiuZ,andCaoW*.(2008)Inhibitionofhepaticgluconeogenesisinprimaryhepatocytesbystromalcell-derivedfactor-1(SDF-1)throughac-Src/Akt-dependentsignalingpathway.JournalofBiologicalChemistry283(45):30642-30649.(影響因子,5.520) 24. LiuHY,Yehuda-ShnaidmanE,HongT,HanJ,LiuZ,PiJ,andCaoW.(2009)Prolongedexposuretoinsulinsuppressesmitochondrialproductioninprimaryhepatocytes.JournalofBiologicalChemistry284(21):14087-14095.(影響因子,5.520) 25. LiuHY*(*equalcontributors),HongT*,WenGB,HanJ,ZhuoD,LiuZ,andCaoW.(2009)IncreasedbasallevelofAkt-dependentinsulinsignalingmayberesponsibleforthedevelopmentofinsulinresistance.AmJPhysiolEndocrinolMetab297:E898-E906.(影響因子,4.230) 26.LiuHY,CaoSY,HongT,HanJ,LiuZ,andCaoW.(2009)Insulinisastrongerinducerofinsulinresistancethanhyperglycemiainmicewithtype1diabetesmellitus(T1DM).JournalofBiologicalChemistry284(40):27090-27100.(影響因子,5.520) 27.LiuHY*(*equalcontributors),HanJ*,CaoSY,HongT,ZhuoD,ShiJ,LiuZ,andCaoW.(2009)HepaticAUTOPHAGYissuppressedinthepresenceofinsulinresistanceandhyperinsulinemia:inhibitionofFoxO1-dependentexpressionofkeyautophagygenesbyinsulin.JournalofBiologicalChemistry284(45):31484-31492.(影響因子,5.520) 28. CaoW,LiuHY,HongTandLiuZ.(2009)Excessexposuretoinsulinmaybetheprimarycauseofinsulinresistance.AmJPhysiolEndocrinolMetab(Inpress).(影響因子,4.230) 劉輝宇-中文論著： 1. 劉輝宇，朱傳琳，姚家佩，等.套用聚合酶鏈反應檢測干擾素治療後HBeAg陰轉B型肝炎病人的HBV-DNA.中華實驗和臨床病毒學雜誌，1993，7:351-354. 2. 姚家佩，趙新如，劉輝宇.輸血或血製品應嚴格掌握適應症.中華實驗和臨床病毒學雜誌，1993，7:304. 3. 張世蘭，宋喜秀，劉輝宇，等.透明質酸檢測在肝病中的診斷價值.中華實驗和臨床病毒學雜誌，1992，6:421-424. 4. 姚家佩，朱傳琳，劉輝宇，等.聚合酶鏈反應在血清乙型抗原抗體反應陰性患者中的初步套用.中華實驗和臨床病毒學雜誌，1992，6:328. 5. 王業東，朱傳琳，劉輝宇，等.套用聚合酶鏈反應檢測無症狀單項抗HBc陽性者血清HBVDNA的意義.中華實驗和臨床病毒學雜誌，1992，6:92-95. 6. 劉輝宇，朱傳琳，姚家佩，等.血清HBV抗原自然陰轉慢性B型肝炎病人的HBV-DNA檢測.中華微生物和免疫學雜誌，1992，12:261. 7. 張玲霞，劉輝宇，朱傳琳，等.B型肝炎病毒表面抗原複合亞型表達病人的臨床分析及病理研究.中華實驗和臨床病毒學雜誌，1991，5:388-391. 8. 劉輝宇，張玲霞，朱傳琳，等.抗前S2檢測在母嬰HBV傳播阻斷中的意義.中華實驗和臨床病毒學雜誌，1991，5:367-370. 9. 朱傳琳，葛安平，劉輝宇，等.Pre-S2/抗Pre-S2慢性HBV感染者的隨訪觀察.中華實驗和臨床病毒學雜誌，1991，5:219-222. 10. 張玲霞，王宇，劉輝宇，等.各型B型肝炎病毒感染者HBsAg亞型的研究.中華實驗和臨床病毒學雜誌，1991，5:111-112. 11. 葛安平，朱傳琳，劉輝宇，等.各型病毒性肝炎血清抗Pre-S2的檢測及其臨床意義.中華實驗和臨床病毒學雜誌，1990，4:197–200. 12. 劉輝宇，尤大棟，朱傳琳，等.慢性病毒性肝炎及肝炎後肝硬變的胰島素拮抗激素和紅細胞胰島素受體特徵.中華實驗和臨床病毒學雜誌，1990，4:193-196. 13. 劉輝宇，張玲霞，朱傳琳，等.銅鋅超氧化物歧化酶測定在病毒性肝炎中的臨床意義.解放軍醫學雜誌，1989，14:283. 14. 劉輝宇，朱傳琳，尤大棟，等.30例急性乙型病毒性肝炎前S2和抗前S2抗體動態變化的意義.中華內科雜誌，1989，28:400-402,443. 15. 劉輝宇，張玲霞，朱傳琳，等.IgA抗-HBc檢測對病毒性B型肝炎的臨床意義.解放軍醫學雜誌，1987，12:335-337. 劉輝宇-綜述及著作: 1. 劉輝宇.無環鳥疳.見：葉濰法，鍾振義主編：肝病治療學.天津科學技術出版社，1993年第二版，第188-191頁. 2. 劉輝宇.成人HSV肝炎(綜述).實用內科雜誌，1989，9:323-325. 3. 劉輝宇.IgA型抗-HBc的研究進展及臨床意義(綜述).國外醫學流行病學傳染病學分冊1988，11:204-207. 劉輝宇-特邀演講: 1.LiuHY.Suppressionofhepaticgluconeogenesisbyhumandefensins,HNP-1andHNP-2.HollingsCancerCenter,MedicalUniversityofSouthCarolina,86JonathanLucasStreet,P.O.Box250955,Charleston,SC29425.May28,2007. 2.LiuHY.SignalingproteinsforTrkreceptortyrosinekinasesinthedevelopmentofneuronsandneuronaltumors.DepartmentofPharmacologyandTherapeutics,UniversityofManitobaFacultyofMedicine,Winnipeg,Manitoba.July28,2004,14:00-16:30P.M. 3.LiuHY.SignalingmoleculesforprotooncogeneTrkreceptortyrosinekinases.NorthwesternOntarioRegionalCancerCentre,LakeheadUniversity,ThunderBay,Ontario.July8,2004,12:00–1:00P.M. 4. LiuHY.Tid-1,ahumanDnaJprotein,associateswiththeTrkfamilyofreceptortyrosinekinases.2002BobKlineSymposium.London,Ontario.October21,2002. 5.LiuHY.Chemokinereceptors,CCR5andCXCR4,mediateCD4-independentinfectionofhumanimmunodeficiencyvirustype2andsimianimmunodeficiencyvirusstarins.The2ndCongressofTheJapaneseResearchSocietyforNeurovirology,Tokyo,Japan.December26,1998. 6.LiuHY.SequenceanalysisoftheV3loopderivedfrombraincapillarytissueofAIDSpatients.The11thCongressofTheJapaneseSocietyforAIDSResearch,Kumamoto,Japan.November5,1997. 7.LiuHY.SingleaminoacidsubstitutionswithintheGPGRsequenceofHIV-1V3loopcanalteritscytopathiceffects.The9thCongressofTheJapaneseSocietyforAIDSResearch,Osaka,Japan.November17,1995. 劉輝宇-學會發表: 1.LiuHY,ChunhuiLi,JamesMacDonaldandMeakinSO.Tid-1,ahumanDnaJprotein,associateswiththeTrkfamilyofreceptortyrosinekinases.HUPO2ndAnnual&IUBMBXIXWorldCongress,Montreal.October8-11,2003 2.LiuHY,ChunhuiLi,JamesMacDonaldandMeakinSO.Tid-1,ahumanDnaJprotein,associateswiththeTrkfamilyofreceptortyrosinekinases.Abstracthasbeensubmittedtothe19thInternationalCongressofBiochemistry&MolecularBiology.July20-24,2003,Toronto,Ontario.(CancelledasoftheSARS). 3. LiuHY,Wenzel-SeifertK,GilleA,SeifertR(2000)FunctionalDifferencesbetweenGS?-shortandGalpha-olf.Naunyn-Schmiedberg’sArchievesofPharmacology362(Suppl):R25. 4.HaraguchiY,LiuHY,SodaY,ShimizuN,JinnoA,KitamoraT,andHoshinoH.TheaminoacidsequenceofV3loopofHIV-1strainswithdiversecell-tropismandtheirchemokinereceptorusages.The11thCongressofTheJapaneseSocietyforAIDSResearch,4-5November1997,p.134,abstract173,Kumamoto,Japan. 5.ShimizuN,HaraguchiY,LiuHY,NakazatoY,HauwJJ,SeilheanD,andHoshinoH.DetectionandgeneticanalysisofHIV-1frombraintissuesofpatientswithAIDSencephalitis.The8thCongressofTheJapaneseSocietyforAIDSResearch,8-9December1994,p.107,abstract7,Sapporo,Japan. 6. LiuHY,ShimizuNG,ShimizuNS,TakeuchiY,andHoshinoH.EstablishmentofhumanTcelllinespersistentlyinfectedwithHIV-1havingasinglepoint-mutationintheV3regiongp120.TheThirdAsia-PacificCongressofMedicalVirology,23-28October1994.Abstractinp.134.Beijing,China. 7.YangDY,OhtaS,YamaguchiY,TsukadaY,HaraguchiY,LiuH-y,etal.Sulfatedcolominicacid:anantiviralagentthatinhibitstheinfectivityofhumanimmunodeficiencyvirustype1invitro.TheTenthInternationalConferenceonAIDSandInternationalConferenceonSTD,7-12August1994,p.34involume1,abstract111A,Yokohama,Japan.
