人物經歷
1982年畢業於原上海第一醫學院藥學系，1988年在美國密西根大學藥學院獲得博士學位。現為美國休斯敦大學藥學院終身教授。此外，還擔任《分子藥劑學》等期刊的編委，以及多種藥學期刊和多項基金的評審。
研究方向
● 黃酮類化合物的吸收與代謝以及調控機理研究
● 藥物吸收、代謝與肝癌、結腸癌等疾病的相關性以及機理研究
主要貢獻
研究領域主要為分子藥劑學，涉及藥物口服吸收、藥物的腸轉運和代謝機理，以及預防癌症的植物藥及其製劑學等。在藥物口服吸收機理研究方面取得了開創性成果，首次定義了“腸腸循環是外來物質體內處置的一個過程”，提出用“旋轉門”理論解釋腸內結合酶與外排體的偶合作用。主持科研項目20餘項，多次獲得美國NIH、NCI等資助，研究經費累計近300萬美元；發表SCI論文30餘篇，累計被引用395次；發表綜述和專著8部。
發表論文
[1] XuB, Gao S, Wu B, Yin T, Hu M*.Absolute quantification of UGT1A1 in various tissues and cell lines usingisotope label-free UPLC-MS/MS method determines its turnover number andcorrelates with its glucuronidation activities. J Pharm Biomed Anal. 2013 Aug29;88C:180-190.
[2] LiuW, Kulkarni K, Hu M*.Gender-dependent differences in uridine 5'-diphospho-glucuronosyltransferasehave implications in metabolism and clearance of xenobiotics. Expert Opin DrugMetab Toxicol. 2013 Sep 6. [Epub ahead of print]
[3] MaG, Wu B, Gao S, Yang Z, Ma Y, Hu M*.Mutual regioselective inhibition of human UGT1A1-mediated glucuronidation offour flavonoids. Mol Pharm. 2013 Aug 5;10(8):2891-903.
[4] WeiY, Wu B, Jiang W, Yin T, Jia X, Basu S, Yang G, Hu M*. Revolving door action of breast cancer resistance protein(BCRP) facilitates or controls the efflux of flavone glucuronides fromUGT1A9-overexpressing HeLa cells. Mol Pharm. 2013 May 6;10(5):1736-50
[5] NiuT, Smith DL, Yang Z, Gao S, Yin T, Jiang ZH, You M, Gibbs RA, Petrosino JF, Hu M*. Bioactivity and bioavailabilityof ginsenosides are dependent on the glycosidase activities of the A/J mouseintestinal microbiome defined by pyrosequencing. Pharm Res. 2013Mar;30(3):836-46.
[6] TamVH, Chang KT, Yang Z, Newman J, Hu M*.In vitro pharmacodynamics of AZD5206 against Staphylococcus aureus. AntimicrobAgents Chemother. 2013 Feb;57(2):1062-4.
[7] XiaB, Zhou Q, Zheng Z, Ye L, Hu M*, LiuZ*. A novel local recycling mechanism that enhances enteric bioavailability offlavonoids and prolongs their residence time in the gut. Mol Pharm. 2012 Nov5;9(11):3246-58.
[8] Kulkarni KH, Yang Z, Tao N, and Hu M*.Effects of Female Sex Hormones on Pharmacokinetics, Absorption and Dispositionof Genistein in Female Sprague Dawley Rats. J. Agric. Food Chem. 2012, in press
[9] Yang Z, Zhu W,Gao S, Yin T, Jiang W, and Hu M*.Breast Cancer Resistance Protein (ABCG2) Determines Distribution of GenisteinPhase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition ofGenistein. Drug Metab Dispos. ePub, 2012
[10] Abdelraouf K,Braggs KH, Yin T, Truong LD, Hu M*,Tam VH*. Characterization of Polymyxin B-induced Nephrotoxicity: Implicationsfor Dosing Regimen Design. Antimicrob Agents Chemother. 2012 Sep;56(9):4625
