![田國寶[中山大學中山醫學院教授]](/img/a/b83/nBnauM3XxUDN3MDN2IDO2czM0MTM2QzMwMDMwADMwAjMxAzLygzL0UzLt92YucmbvRWdo5Cd0FmL0E2LvoDc0RHa.jpg "田國寶[中山大學中山醫學院教授]")
研究方向：細菌耐藥機制
研究興趣
1.臨床病原細菌對β-內醯胺類藥物、多粘菌素類藥物和替加環素耐藥機制研究
2.結核分枝桿菌耐藥機制研究
3.耐藥基因的分子生物學檢測方法建立
4.細菌耐藥阻斷劑和新型抗生素複方製劑研發
主要學術任職
1.中國微生物學會醫學微生物學與免疫學專委會第一屆青年委員會委員
2.中國防癆協會青年理事會委員
3.全國高等教育醫學數位化規劃教材《醫學微生物學》編委
4.美國微生物學會(American Society for Microbiology，ASM)會員
5.國家和廣東省自然科學基金項目評審專家
6.Clinical Infectious Diseases、Journal of Antimicrobial Chemotherapy 、Antimicrobial Agents and Chemotherapy、Clinical Microbiology and Infection、Oncotarget等雜誌審稿專家
科研項目
1. “廣東特支計畫”百千萬工程青年拔尖人才，2016，細菌耐藥性
2.高校基本科研業務費青年教師重點培育項目，16ykzd09，耐碳青黴稀類藥物“超級細菌”的耐藥傳播分子機制及臨床治療，主持
3.國家自然科學基金項目，81471988，新型超廣譜β-內醯胺酶PME耐藥傳播分子機制，主持
4.國家重點研發計畫，2016YFC1200100，輸入性傳染病的輸入機制與播散規律，核心骨幹
5.廣東省科技發展專項，2016A020219002，動物和人源產碳青黴烯酶超級細菌的流行病學和傳播機制比較研究，主持
6.廣州市珠江新星專項，2014J2200038，廣東產新型超廣譜β-內醯胺酶PME耐藥傳播分子機制及風險，主持
7.廣東省自然科學基金項目，S2013010015810，廣東PME酶學功能及耐藥傳播分子機制，主持
8.國家重大科技專項“十二五”計畫課題，2013ZX10003001，結核病新型診斷產品研發及其產業化，子任務負責人
9.廣東省海洋經濟創新發展區域示範專項項目，GDHY2012-01-001，海洋生物天然產物化合物庫，參與
10.國家自然科學基金項目，81201325，產CTX-M-15多重耐藥E.coliST131耐藥傳播分子機制研究，主持
11.廣東省自然科學基金項目，廣東地區產CTX-M-15多重耐藥E.coliST131耐藥傳播分子機制研究，主持
獲獎
1.廣州市珠江科技新星
2.高校基本科研業務費青年教師重點培育項目
3.“廣東特支計畫”百千萬工程青年拔尖人才
4.廣東省高等院校“千百十工程”第七批校級培養對象
5.所屬“抗感染免疫”團隊被授予“第四屆中國僑界貢獻(創新團隊)獎”
6.國家科技進步獎二等獎
7.四川省科學技術進步一等獎
8.中山醫學院優秀黨務工作者
9.中山醫學院教學質量獎
代表性論文
1.Lan-Lan Zhong，Nicole Stoesser，Yohei Doi，Cong Shen，Xi Huang，Guo-Bao Tian*（通訊作者），Carriageof β-lactamase-producing Enterobacteriaceae by Chinese travellers，Lancet Infectious Diseases，2017.2.1，17. 影響因子22.433
Yang Wang*, Guo-Bao Tian*（共同第一作者）, Rong Zhang, Yingbo Shen, Jonathan M. Tyrrell, Xi Huang, Hongwei Zhou, Lei Lei, Hong-Yu Li, Yohei Doi, Ying Fang, Hongwei Ren, Lan-Lan Zhong, Zhangqi Shen, Kun-Jiao Zeng, Shaolin Wang, Jian-Hua Liu, Congming Wu, Timothy R. Walsh, Jianzhong Shen.Clinical associations and molecular epidemiology of mcr-1-positive Escherichia coli in patients and as normal human flora from China: an epidemiology and clinical study. Lancet Infectious Diseases.accepted. 影響因子22.433
Lan-Lan Zhong, Yan-Fen Zhang, Yohei Doi, Xi Huang, Xue-Fei Zhang, Kun-Jiao Zeng, Cong She, Sandip Patil, Yong Xing, Yutian Zou, Guo-Bao Tian*（通訊作者）. Co-production of MCR-1 and NDM-1 by colistin-resistantEscherichia coli isolated from a healthy individual. Antimicrobial Agents and Chemotherapy. 2016 Nov 7. pii: AAC.01962-16. 影響因子4.451.
Zhang XF, Doi Y, Huang X, Li HY, Zhong LL, Zeng KJ, Zhang YF, Patil S, Tian GB（通訊作者）. Possible Transmission of mcr-1-Harboring Escherichia coli between Companion Animals and Human. Emerg Infect Dis. 2016 Sep 15;22(9). doi: 10.3201/eid2209.160464. 影響因子6.994.
Zeng KJ, Doi Y, Patil S, Huang X, Tian GB（通訊作者）. Emergence of the Plasmid-Mediated mcr-1 Gene in Colistin-Resistant Enterobacter aerogenes and Enterobacter cloacae. Antimicrob Agents Chemother. 2016 May 23;60(6):3862-3. doi: 10.1128/AAC.00345-16. 影響因子4.451
Tian GB（第一作者）, Jiang YQ, Huang YM, Qin Y, Feng LQ, Zhang XF, Li HY, Zhong LL, Zeng KJ, Patil S, Xing Y, Huang X. Characterization of CTX-M-140, a Variant of CTX-M-14 Extended-Spectrum β-Lactamase (ESBL) with Decreased Cephalosporin Hydrolytic Activity, from Cephalosporin-Resistant Proteus mirabilis. Antimicrob Agents Chemother. 2016 Aug 1. pii: AAC.00822-16. 影響因子4.451.
Huang YM, Zhong LL, Zhang XF, Hu HT, Li YQ, Yang XR, Feng LQ, Huang X, Tian GB（通訊作者）. NDM-1-Producing Citrobacter freundii, Escherichia coli, and Acinetobacter baumannii Identified from a Single Patient in China. Antimicrob Agents Chemother. 2015 Aug;59(8):5073-7. doi: 10.1128/AAC.04682-14.
Guo-Bao Tian（共同第一作者）, Ying-Min Huang, Zhi-Li Fang, Yun Qing, Xue-Fei Zhang, Xi Huang.CTX-M-137, a Hybrid of CTX-M-14-Like and CTX-M-15-Likeβ-Lactamases Identified in anEscherichia coliClinical Isolate.J Antimicrob Chemother. 2014;69(8):2081-5.
Qing Y, Cao KY, Fang ZL, Huang YM, Zhang XF,Tian GB（共同通訊作者）, Huang X. Outbreak of PER-1 and Diversity of β-Lactamases among Ceftazidime-ResistantPseudomonas aeruginosaClinical Isolates in China. J Med Microbiol. 2014 Jan 7. doi: 10.1099/jmm.0.069427-0.[Epub ahead of print].
Fang ZL, Zhang LY, Huang YM, Qing Y, Cao KY,Tian GB（共同通訊作者）, Huang X. OprD mutations and inactivation in imipenem-resistantPseudomonas aeruginosaisolates from China. Infect Genet Evol. 2014; 21:124-8.
Guo-Bao Tian（第一作者）, Hong-Ning Wang, An-Yun Zhang, Yi Zhang, Wen-Qiao Fan, Chang-Wen Xu, Bo Zeng, Zhong-Bin Guan, Li-Kou Zou. Detection of clinically important β-lactamases in commensal Escherichia coli of human and swine origin in western China. Journal of Medical Microbiology (ISSN: 0022-2615). 2012; 61(Pt 2):233-8.
Guo-Bao Tian（第一作者）, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Anthony W. Pasculle, John P. Quinn, Hong-Ning Wang, Yohei Doi. Identification of Diverse OXA-40-Group Carbapenemases Including a Novel Variant, OXA-160, fromAcinetobacter baumanniiin Pennsylvania.Antimicrob Agents Chemother.2010; 55:429-32.
Guo-Bao Tian（第一作者）, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Hong-Ning Wang, Yohei Doi. PME-1, an Extended-Spectrum β-lactamase Identified inPseudomonas aeruginosa.Antimicrob Agents Chemother. 2011; 55: 2710-2713.
Guo-Bao Tian（第一作者）, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Yohei Doi. Sequence Type ST405Escherichia coliIsolate Producing QepA1, CTX-M-15, and RmtB from Detroit, Michigan.Antimicrob Agents Chemother. 2011; 55: 3966-3967.
Guo-Bao Tian（第一作者）, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Hong-Ning Wang, Yohei Doi. Extended-Spectrum AmpC inAcinetobacter baumanniiADC-56 Confers Resistance to cefepime.Antimicrob Agents Chemother. 2011; 55: 4922-4925.
Guo-Bao Tian（第一作者）, Wang Hong-ning, Li-Kou Zou, etc. Detection of clinically important β-lactamases in commensalEscherichia coliof human and swine origin in western China.J Med Microbiol. 2012 61(2):233-8.
Guo-Bao Tian（第一作者）, Jemelyn Garcia, Jennifer M. Adams-Haduch, Jennifer P. Evangelista, Raul V. Destura, Hong-Ning Wang, Yohei Doi. CTX-M as the predominant extended-spectrum b-Lactamase amongEnterobacteriaceaein Manila, Philippines.J Antimicrob Chemother. 2010; 65: 584-6.
Guo-Bao Tian（第一作者）, Jennifer M. Adams-Haduch, Zubair A. Qureshi, Hong-Ning Wang, Yohei Doi. CTX-M-35 Extended-Spectrum b-Lactamase Conferring Ceftazidime Resistance inCitrobacter koserii.International Journal of Antimicrobial Agents. 2010; 35: 412-3.
Guo-Bao Tian（第一作者）,Wang Hong-ning, Li-Kou Zou, etc. Detection of CTX-M-15, CTX-M-22, and SHV-2 Extended-Spectrum bata-Lactamases (ESBLs) inEscherichia coliFecal-Sample Isolates from Pig Farms in China.Foodborne Pathogens and Disease. 2009; 6:297-304.
Rongsui Gao,Yongfei Hu,Zhencui Li,Jian Sun,Qingjing Wang,Jingxia Lin,Huiyan Ye,Fei Liu,Swaminath Srinivas, Defeng Li,Baoli Zhu,Ya-Hong Liu,Guo-Bao Tian（合作作者）,Youjun Feng. Dissemination and Mechanism for the MCR-1 Colistin Resistance.PLOS Pathogens.
Yi-Yun Liu, Yang Wang, Timothy R Walsh, Ling-Xian Yi, Rong Zhang, James Spencer, Yohei Doi, Guo-bao Tian（合作作者）, Baolei Dong, Xianhui Huang, Lin-Feng Yu, Danxia Gu, Hongwei Ren, Xiaojie Chen, Luchao Lv, Dandan He, Hongwei Zhou, Zisen Liang, Jian-Hua Liu, Jianzhong Shen. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infectious Diseases (ISSN: 1473-3099). 2016; 16(2):161-8. doi: 10.1016/S1473-3099(15)00424-7.
Hanna E. Sidjabat, David L. Paterson, Jennifer M. Adams-Haduch, Lindsay Ewan, Anthony W. Pasculle, Carlene A. Muto,Guo-Bao Tian, and Yohei Doi. Molecular Epidemiology of CTX-M-ProducingEscherichia coliIsolates at a Tertiary Medical Center in Western Pennsylvania.Antimicrob Agents Chemother2009; 53: 4733-9.
Rebecca I. Waltner-Toews, David L. Paterson, Zubair A. Qureshi, Hanna E. Sidjabat, Jennifer M. Adams-Haduch, Kathleen A. Shutt, Mark Jones,Guo-Bao Tian, Anthony W. Pasculle, and Yohei Doi. Clinical Characteristics of Bloodstream Infections Due to Ampicillin/Sulbactam-Resistant, Non-ESBL-ProducingEscherichia coliand the Role of TEM-1 Hyperproduction.Antimicrob Agents Chemother. 2011; 55: 495-501.
Tatiana Bogdanovich, Jennifer M. Adams-Haduch,Guo-Bao Tian, Hong M. Nguyen, Eun J. Kwak, Carlene A. Muto, Yohei Doi. Colistin ResistantKlebsiella pneumoniaeCarbapenemase (KPC) ProducingKlebsiella pneumoniaeBelonging to the International Epidemic Clone ST258.Clinical Infectious Diseases. 2011; 53: 373-376.
Jennifer M. Adams-Haduch, Ezenwa O. Onuoha, Tatiana Bodganovich,Guo-Bao Tian, Jonas Marschall, Carl Urban, Brad Spellberg, Diane Rhee, Diane Halstead, Anthony W. Pasculle, Yohei Doi. Contemporary Molecular Epidemiology of Carbapenem-ResistantAcinetobacter baumanniiin the United States.J Clin Microbiol. 2011;49(11):3849-54.
1.Guo-Bao Tian*
2.*
3.Guo-Bao Tian
4.Tian GB
5.Tian GB
6.Tian GB
7.Tian GB
8.Guo-Bao Tian
9.Tian GB
10.Tian GB
11.Guo-Bao Tian
12.Guo-Bao Tian
13.Guo-Bao Tian
14.Guo-Bao Tian
15.Guo-Bao Tian
16.Guo-Bao Tian
17.Guo-Bao Tian
18.Guo-Bao Tian
19.Guo-Bao Tian
20.Guo-Bao Tian
21.Guo-bao Tian
22.Guo-Bao Tian
23.Guo-Bao Tian
24.Guo-Bao Tian
25.Guo-Bao Tian
招聘信息
本實驗室常年招聘以下研究人員：
1. 特聘研究員：38周歲以下，博士，有4項及以上代表性學術成果。工資稅前30-36萬/年
2. 特聘副研究員：38周歲以下，博士，有2項及以上代表性學術成果。工資稅前19-25萬/年
3. 助理研究員：35周歲以下，博士或特別優秀的碩士。工資稅前14-16萬/年
4. 博士後：35周歲以下，國內外知名高校或研究機構的博士畢業生。工資稅前12-16萬/年
歡迎有醫學、生命科學、生物信息學等相關研究背景的人員與本人聯繫。
