王燕銘[中國南開大學藥學院副教授]

王燕銘 性別：男 職稱：南開大學藥學院副教授 學科方向：化學生物學、藥劑學

招生方向：生物材料、化學生物學、藥劑學

教師簡介

藥物化學生物學國家重點實驗室固定成員，南開大學生命科學學院生物活性材料教育部重點實驗室固定成員，高分子化學博士，生物化學博士後。1999年7月畢業於南開大學化學學院化學專業，獲學士學位，同年9月於南開大學生命科學學院生物活性材料教育部重點試驗直接攻讀高分子化學與物理專業博士學位，從事樹枝狀高分子用於非病毒高分子基因載體的合成及性能研究。2005年9月於南開大學生命科學學院生物學流動站做博士後，研究方向為癌細胞靶向高分子基因載體的合成及性能研究。2007年博士後出站後留南開大學藥學院工作至今，主要從事功能性高分子材料和雜化材料的化學生物學性質以及藥物和基因控釋研究。

代表性作品

1. Yanming Wang, Yajie Wang, Ling Wang, Yongzhe Che, Zongjin Li, Deling Kong. Preparation and evaluation of magnetic nanoparticles in cell labeling. J. Nanosci. Nanotech, 2011; in published.

2. Yanming Wang, Weiling Kong, Yu Song, Yajun Duan, Lianyong Wang, Gustav Steinhoff, Deling Kong, Yaoting Yu. Polyamidoamine Dendrimers with a Modified Pentaerythritol Core Having High Efficiency and Low Cytotoxicity as Gene Carriers. Biomacromolecules. 2009, 10(3), 617–622.

3. Yue Zhang, Xibo Yan, Bo Dong, Nan Shi, Jing Li, Yanming Wang*, Peng George Wang*. Effectively Suicide Gene Therapy Delivered in vitro using Polyamidoamine Dendrimer (PAMAM) with a Modified Pentaerythritol Core. Hum Gene Ther. 2011, in revision.

4. Yue Zhang, Bo Dong, Nan Shi, Jinghua Han, Jing Li, Yanming Wang*, Peng George Wang*. Effecient siRNA Delivery using Polyamidoamine Dendrimer and Cellualr Uptake Pathway Study. Pharmaceutical Research. 2011, in revision.

5. Yue Zhang, Xibo Yan, Bo Dong, Nan Shi, Jinghua Han, Xin Wang, Yanming Wang*, Peng George Wang*. A facile entrapment approach to construct PEGylated polyplexes for improving stability of gene delivery in physiological condition. Colloids and Surfaces B: Biointerfaces. 2011, in revision.

6. Xibo Yan, Yue Zhang, Xiaoqian Li, Bo Dong, Xin Wang*, Yanming Wang*. Amphiphilic Polyethylenimine (PEI) as High efficient non-viral gene carrier. Org.biomol.chem. 2011, submitted.

7. Jianfeng Liu, Jinjian Liu, Liping Chu, Yanming Wang, Yajun Duan, Lina Feng, Cuihong Yang, Ling Wang, Deling Kong. Novel peptide-dendrimer conjugates as drug carriers for targeting nonsmall cell lung cancer. International Journal of Nanomedicine, 2011:6 59–69.

8. Zhang Z, Yang C, Duan Y, Wang Y, Liu J, Wang L, Kong D. Poly (ethylene glycol) analogs grafted with low molecular weight of poly(ethylenimine) as nonviral gene vectors. Acta Biomater. 2010 Jul; 6(7):2650-7.

9. Yajun Duana, Junnian Zheng, Sufang Hana, Yi Wu, Yanming Wang, Deguan Li, Deling Kong and Yaoting Yu. A tumor targeted gene vector modified with G250 monoclonal antibody for gene therapy. Journal of controlled release. 2008, 127(2), 173-179.

10. Wang Yanming, Zhang Zhenfang, Yu Qi, Wang Lianyong, Kong Deling, Yu Yaoting. Properties of Poly[L-(aspartic acid)-co-L-lysine] Grafted with Cholesterol Conjugated Low Molecular Weight Poly(ethylen imine) for Gene Delivery. Chemical Journal of Chinese Universities，2008(10), 2011-2014.

11. Wang Yanming, Song yu, Kong Deling, Yu yaoting. Interaction between poly(amidoamine) dendrimers and DNA studied by spectroscopic methods. Chinese Science Bulletin. 2005, 50(19): 2161-2165

12. Wang Yanming, Song yu, Kong Deling, Yu yaoting. Fluorescence studies on the interactions of PAMAM dendrimers and their derivatives with bovine serum albumin. Chinese Science Bulletin. 2005, 50(21): 2436-2441.

13. Han Sufang , Duan Yajun , Wang Yanming , Zheng Junnian , Wu Yi , Cai Rong , Ou Lail iang, Kong Deling, Yu Yaoting. Tumor Targeted Gene Vector Modified with G250 Monoclonal Antibody for Gene Therapy. Chemical Journal of Chinese Universities，2008(5)，923-926.

14. Zhao Weiming, Xu Yong, Wang Yanming, Cheng Zhaokang, Zhang Suai, Yu qi, Kong Deling. HSV-tk gene delivered by chitosan nanoparticles killed prostate cancer cells in vitro. Tumor, 2007, 27(3), 210-213.

15. Zhao Weiming, Xu Yong, Wang Yanming, Cheng Zhaokang, Yu qi, Kong Deling. Generation 5 polyamidoamine dendrimers mediated experimental HSV-tk gene therapy in murine prostate cancer models. China Oncology, 2007, 17(3), 225-229.

16. Yuan Yi, Wang Yanming, Yu Yaoting. Study of the LDL adsorbent with dendrimer PAMAM as the spacer. Ion exchange and adsorption. 2008, 24(1), 1-9.