![王海濱[中國科學院動物研究所研究員]](/img/3/1a2/nBnauM3X4QTNzQTNxITO0EDN0UTMyITNykTO0EDMwAjMwUzLykzL0EzLt92YucmbvRWdo5Cd0FmLxE2LvoDc0RHa.jpg "王海濱[中國科學院動物研究所研究員]")
人物經歷
王海濱，男，1974年9月出生於浙江省義烏市，博士，研究員，博士生導師；中國科學院動物研究所胚胎著床生理學研究組組長。
社會任職
•美國生殖生物學學會（Society for the Study of Reproduction）會員（2001-）
•美國內分泌學會（Endocrine Society）會員（2004-）
•美國生殖免疫學會（American Society of Reproductive Immunology）會員（2010-）
•Am J ReprodImmunol雜誌編委會委員（2010-）
•PLoS ONE雜誌編委會委員（2010-）
•Reprod Med Biol雜誌編委會委員（2011-）
•Development & Reproduction雜誌編委會委員（2011-）
•Biol Reprod雜誌編委會委員（2012-）
•Invited Guess Editor, Molecular Aspects of Medicine. 2013年特刊：Regulation of Early Pregnancy
•Invited Guess Editor, International Journal of Endocrinology. 2013年特刊：Endocannabinoids and Reproduction
此外，是領域內許多國際刊物，如Nat Med、JCI、JAMA、JBC、Mol Endocrinol、Endocrinology、Biol Reprod、Reproduction、Hum Reprod、Mol Hum Reprod、Fertil Steril、PLoS ONE、BMC Genomics、Placenta等的ad hoc審稿
獲獎記錄
北美產科研究學會Solvay/Joseph Mortola研究獎（2005年）
“百人計畫”引進國外傑出人才（2008年）
國家傑出青年基金獲得者（2008年）
973首席科學家（2011年）
科研項目
•基金委重點項目-母-胎互作微環境決定妊娠結局的分子基礎（81130009），2012-2016
•青年科學基金項目-組蛋白H2A 泛素E3 連線酶Bmi1 和Mel18 在胚胎著床中的作用（31200881），2012-2015
•國家傑出青年基金項目-胚胎髮育與著床/Wnt信號通路在胚泡著床和子宮蛻膜反應中的生理作用（30825015），2009-2012
•國家重大科學研究計畫（973）項目-妊娠建立和維持的分子機制研究（2011CB944400）2011-2015
•國家重大基礎研究（973）項目“卵巢衰老及相關重大疾病的基礎研究”二級課題-卵巢衰老誘發女性生殖系統疾病的分子機理（2010CB945002），2010-2015
主要論著
Lu J, Zhang S, Nakano N, Simmons DG, Wang S, Wang Q, Kong S, Shen L, Wang W, Wang B, Wang HM, Wang YL, van Es JH, Clevers H, Leone G, Cross JC,Wang H*. A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.PLoS Biology.2013.11(4)
Zhang S, Lin H, Kong S, Wang S, Wang H,Wang H*, Armant DR*(Co-correspondence)..Physiological and molecular determinants of embryo implantation.Mol Aspects Med.2013 Jan 2. doi:pii: S0098-2997(12)00158-6. 10.1016/j.mam.2012.12.011. [Epub ahead of print]
Wang Q, Lu J, Zhang S, Wang S, Wang W, Wang B, Wang F, Chen Q, Duan E, Leitges M, Kispert A,Wang H*. Wnt6 is essential for stromal cell proliferation during decidualization in mice.Biol Reprod.88(1):5, 2013
Zhang S, Kong S, Lu J, Wang Q, Chen Y, Wang W, Wang B,Wang H*. Deciphering the molecular basis of uterine receptivity.Mol Reprod Dev.80(1):8-21, 2013
Kong S, Zhang S, Chen Y, Wang W, Wang B, Chen Q, Duan E*,Wang H*. Determinants of uterine aging: lessons from rodent models.Sci China Life Sci.55(8): 687-93, 2012
Lim H &Wang H* (Co-correspondence). Uterine disorders and pregnancy complications: insights from mouse models.J CIin Invest. 120(4), 1004-15, 2010
Chen Q, Zhang Y, Lu J, Wang Q, Wang S, Cao Y,Wang H*, Duan E* (Co-correspondence). Embryo-uterine cross-talk during implantation: The role of Wnt signaling.Mol Hum Reprod. 15(4):215-21, 2009
Xie H, Tranguch S, Jia X, Zhang H, Das SK, Dey SK,Kuo CJ, andWang H* (*Correspondence). Inactivation of Nuclear Wnt-β-Catenin Signaling Limits Blastocyst Competency for Implantation.Development. 135(4): 717-727, 2008
Wang H*, Xie H*(equal contribution), Dey SK. Loss of cannabinoid receptor CB1 induces preterm birth.PLoS ONE. 3(10):e3320, 2008
Xie H*,Wang H* (equal contribution), Tranguch S, Iwamoto R, Mekada E, DeMayo FJ, Lydon JP, Das SK and Dey SK. Heparin-binding EGF-like growth factor serves as a molecular link between the blastocyst and uterus during implantation.PNAS. 104(46): 18315-20, 2007
Wang H*, Xie H* (equal contribution), Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN and Dey SK. Stage-specific integration of maternal and embryonic PPARδ signaling is critical to pregnancy success.J Biol Chem.282(52): 37770-37782, 2007
Wang H*, Xie H*, Sun X* (equal contribution), Kingsley PJ, Marnett LJ, Cravatt BF and Dey SK. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation.Prostaglandins Other Lipid Mediat.83(1-2): 62-74, 2007
Wang H*, Xie H, Guo Y, Zhang H, Takahashi T, Kingsley PJ, Marnett LJ, Das SK, Cravatt BF and Dey SK. Fatty acid amide hydrolase deficiency limits early pregnancy events.J CIin Invest.116 (8): 2122-2131, 2006
Wang H*, Dey SK and Maccarrone M. Jekyll and Hyde: Two faces of cannabinoid signaling in male and female fertility.Endocr Rev. 27 (5): 427-448, 2006
Wang H*and Dey SK. Roadmap to embryo implantation: Clues from mouse models.Nat Rev Genet. 7 (3): 185-199, 2006
Wang H*, Xie H and Dey SK. Endocannabinoid signaling directs periimplantation events.AAPS J. 8 (2): E425-E432, 2006
Wang H*, Xie H* (equal contribution), Zhang H, Das SK and Dey SK. Conditional gene recombination by adenovirus-driven Cre in the mouse uterus.Genesis. 44(2): 51-56, 2006
Lei L, Zhang H, Jin S, Wang F, Fu M,Wang H* and Xia G* (co-correspondence). Stage-specific germ-somatic cell interaction directs the primordial folliculogenesis in mouse fetal ovaries.J Cell Physiol. 208(3): 640-647, 2006
Wang H*, Tranguch S* (equal author), Xie H, Hanley G, Das SK, Dey SK. Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus.PNAS. 102 (28): 9960-9965, 2005
Wang H*and Dey SK. Lipid Signaling in Embryo Implantation.Prostaglandins Other Lipid Mediat. 77(1-4): 84-102, 2005
Guo Y*,Wang H*(equal author), Okamoto Y, Ueda N, Kingsley PJ, Marnett LJ, Schmid HH, Das SK, Dey SK. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation.J Biol Chem.280 (25): 23429-23432, 2004
Wang H*, Ma W, Tejada L, Zhang H, Morrow JD, Das SK, and Dey SK. Rescue of female infertility from the loss of Cyclooxygenase-2 by compensatory upregulation of Cyclooxygenase-1 is a function of genetic make-up.J Biol Chem.279(11): 10649-10658, 2004
Wang H*, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN and Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos.Nat Med.10(10): 1074-1080, 2004
Wang H*, Matsumoto H, Guo Y, Paria BC, Roberts RL, and Dey SK. Differential G-Protein coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation.PNAS. 100(25): 14914-14919, 2003
Wang H*, Herath CB, Xia GL, Watanabe G, and Taya K. Superovulation, fertilization and in vitro embryo development in the mouse after administration of inhibin-neutralizing antiserum.Reproduction. 122(5): 809-816, 2001
1.PLoS Biology.
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3.Biol Reprod.
4.Mol Reprod Dev.
5.Sci China Life Sci.
6.J CIin Invest
7.Mol Hum Reprod
8.Development
9.PLoS ONE
10.PNAS
11.J Biol Chem
12.Prostaglandins Other Lipid Mediat
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17.Genesis
18.J Cell Physiol
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24.PNAS
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