![李棟[北京蛋白質組研究中心研究員]](/img/f/f78/nBnauM3XxcDNyEzM1QzM1kTO0UTMyITNykTO0EDMwAjMwUzL0MzL0AzLt92YucmbvRWdo5Cd0FmLzE2LvoDc0RHa.jpg "李棟[北京蛋白質組研究中心研究員]")
研究方向 ：
主要從事蛋白質組生物信息學研究，致力於從生物醫學大數據中進行知識的發現。承擔國家精準醫學、國家國際科技合作專項和國家自然科學基金等各類項目9項，首次整合多生物學證據進行高通量蛋白質相互作用數據的可靠性分析；建立國際上首個基於蛋白質網路預測信號通路的生物信息算法系統；首次揭示蛋白質相互作用網路拓撲上的“保守直徑”現象和為進化上的“蛋白質成簇添加”現象提供模體層次的證據； 建立大規模組學數據可視化和分析軟體平台，為國內外提供數據分析服務25000多次；對最大規模組織層次蛋白質網路——肝臟蛋白質相互作用網路進行研究。在Nature Communications, Molecular&Cellular Proteomics, Molecular Systems Biology和J Proteome Res等期刊發表第一/通訊作者（含並列）署名SCI論文19篇，累計影響因子110，發表其他署名SCI論文20篇，獲國家科技進步創新團隊獎等國家和省部級獎勵5次，獲軟體著作權28項。
發表第一/責任作者論文 ：
Yang Li#, Ping Xie#, Liang Lu#, Jian Wang, Lihong Diao, Zhongyang Liu, Feifei Guo, Yangzhige He, Yuan Liu, Qin Huang, Han Liang, Dong Li* & Fuchu He*. An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.Nature Communications,2017, 8: 347
Dong Li, Wanlin Liu, Zhongyang Liu, Jian Wang, Yunping Zhu, Fuchu He, PRINCESS: a PRotein INteraction Confidence Evaluation System with multiple data Sources.Molecular & Cellular Proteomics, 2008, Jun 7: 1043-1052.
Liu Z, Guo F, Zhang J, Wang J, Lu L, Li D*, He F*. Proteome-wide prediction of self-interacting proteins based on multiple properties.Mol Cell Proteomics. 2013 Jun;12(6):1689-700.
Liu W*, Li D*, Wang J, Xie H，Zhu Y, He F, Proteome-wide prediction of signal flow direction in protein interaction network based on interacting domains.Molecular & Cellular Proteomics, 2009, Sep;8(9):2063-70.
Guo F, Wang D, Liu Z, Lu L, Zhang W, Sun H, Zhang H, Ma J, Wu S, Li N, Jiang Y, Zhu W, Qin J, Xu P, Li D*, He F*. CAPER: a Chromosome-Assembled human Proteome browsER.J Proteome Res.2013 Jan 4;12(1):179-86.
Wang, Dan; Liu, Zhongyang; Guo, Feifei; Diao, Lihong; Li, Yang; Zhang, Xinlei; Huang, Zechi; Li, Dong*; He, Fuchu*, CAPER2.0: an interactive, configurable and extensible workflow-based platform to analyze datasets from the Chromosome-centric Human Proteome Project,J Proteome Res,2014, 13: 99-106.
Shuai Yang , Xinlei Zhang , Hongli Diao , Feifei Guo , Dan Wang , Zhongyang Liu , Honglei Li , Junjie Zheng , Jingshan Pan , Edouard C. Nice , Dong Li* , and Fuchu He*. CAPER 3.0: a scalable cloud-based system for data-intensive analysis of Chromosome-centric Human Proteome Project datasets.J. Proteome Res., 2015, 14: 3720-8.
Jian Wang*, Keke Huo*, Lixin Ma*, Liujun Tang*, Dong Li*, et al., Toward an understanding of the protein interaction network of the human liver.Molecular Systems Biology,2011 7: 536.
Li D, Li J, Ouyang S, Wang J, et al., Protein Interaction Networks of Saccharomyces cerevisiae, Caenorhabditis elegans andDrosophila melanogaster: Large-Scale Organization and Robustness,Proteomics,2006, Jan, 6:456-461.
LI Dong, LI Jian-Qi, OUYANG Shu-Guang, WANG Jian, et al., An Integrated Strategy for Functional Analysis in Large-scale Proteomic Research by Gene Ontology,Progress in Biochemistry and Biophysics,2005, 32: 1026 - 1029.
Zhongyang Liu, Feifei Guo, Jiangyong Gu, Yong Wang, Yang Li, Dan Wang, Liang Lu, Dong Li*, and Fuchu He*. Similarity-based prediction for Anatomical Therapeutic Chemical classification of drugs by integrating multiple data sources,Bioinformatics,2015，31：1788-95.
Liu Z, Liu Q, Sun H, Hou L, Guo H, Zhu Y, Li D*, He F*. Evidence for the additions of clustered interacting nodes during the evolution of protein interaction networks from network motifs.BMC Evol Biol.2011; May, 11(1):133.
Sun H *, Li D*, Wang J, Liu Z, Xie H, Zhu Y, He F, PNmerger: a Cytoscape plugin to merge biological pathways and protein interaction networks.Prog Biochem Biophys,2009, 36: 1613-1616.
Wanlin Liu, Dong Li*, Qijun Liu, Yunping Zhu and Fuchu He, A novel parametric approach to mine gene regulatory relationship from microarray datasets,BMC bioinformatics,2010, 11: S15.
1.Yang Li#, Ping Xie#, Liang Lu#, Jian Wang, Lihong Diao, Zhongyang Liu, Feifei Guo, Yangzhige He, Yuan Liu, Qin Huang, Han Liang, Dong Li* & Fuchu He*. An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.Nature Communications,2017, 8: 347
2.Dong Li, Wanlin Liu, Zhongyang Liu, Jian Wang, Yunping Zhu, Fuchu He, PRINCESS: a PRotein INteraction Confidence Evaluation System with multiple data Sources.Molecular & Cellular Proteomics, 2008, Jun 7: 1043-1052.
3.Liu Z, Guo F, Zhang J, Wang J, Lu L, Li D*, He F*. Proteome-wide prediction of self-interacting proteins based on multiple properties.Mol Cell Proteomics. 2013 Jun;12(6):1689-700.
4.Liu W*, Li D*, Wang J, Xie H，Zhu Y, He F, Proteome-wide prediction of signal flow direction in protein interaction network based on interacting domains.Molecular & Cellular Proteomics, 2009, Sep;8(9):2063-70.
5.Guo F, Wang D, Liu Z, Lu L, Zhang W, Sun H, Zhang H, Ma J, Wu S, Li N, Jiang Y, Zhu W, Qin J, Xu P, Li D*, He F*. CAPER: a Chromosome-Assembled human Proteome browsER.J Proteome Res.2013 Jan 4;12(1):179-86.
6.Wang, Dan; Liu, Zhongyang; Guo, Feifei; Diao, Lihong; Li, Yang; Zhang, Xinlei; Huang, Zechi; Li, Dong*; He, Fuchu*, CAPER2.0: an interactive, configurable and extensible workflow-based platform to analyze datasets from the Chromosome-centric Human Proteome Project,J Proteome Res,2014, 13: 99-106.
7.Shuai Yang , Xinlei Zhang , Hongli Diao , Feifei Guo , Dan Wang , Zhongyang Liu , Honglei Li , Junjie Zheng , Jingshan Pan , Edouard C. Nice , Dong Li* , and Fuchu He*. CAPER 3.0: a scalable cloud-based system for data-intensive analysis of Chromosome-centric Human Proteome Project datasets.J. Proteome Res., 2015, 14: 3720-8.
8.Jian Wang*, Keke Huo*, Lixin Ma*, Liujun Tang*, Dong Li*, et al., Toward an understanding of the protein interaction network of the human liver.Molecular Systems Biology,2011 7: 536.
9.Li D, Li J, Ouyang S, Wang J, et al., Protein Interaction Networks of Saccharomyces cerevisiae, Caenorhabditis elegans andDrosophila melanogaster: Large-Scale Organization and Robustness,Proteomics,2006, Jan, 6:456-461.
10.LI Dong, LI Jian-Qi, OUYANG Shu-Guang, WANG Jian, et al., An Integrated Strategy for Functional Analysis in Large-scale Proteomic Research by Gene Ontology,Progress in Biochemistry and Biophysics,2005, 32: 1026 - 1029.
11.Zhongyang Liu, Feifei Guo, Jiangyong Gu, Yong Wang, Yang Li, Dan Wang, Liang Lu, Dong Li*, and Fuchu He*. Similarity-based prediction for Anatomical Therapeutic Chemical classification of drugs by integrating multiple data sources,Bioinformatics,2015，31：1788-95.
12.Liu Z, Liu Q, Sun H, Hou L, Guo H, Zhu Y, Li D*, He F*. Evidence for the additions of clustered interacting nodes during the evolution of protein interaction networks from network motifs.BMC Evol Biol.2011; May, 11(1):133.
13.Sun H *, Li D*, Wang J, Liu Z, Xie H, Zhu Y, He F, PNmerger: a Cytoscape plugin to merge biological pathways and protein interaction networks.Prog Biochem Biophys,2009, 36: 1613-1616.
14.Wanlin Liu, Dong Li*, Qijun Liu, Yunping Zhu and Fuchu He, A novel parametric approach to mine gene regulatory relationship from microarray datasets,BMC bioinformatics,2010, 11: S15.
