崔紅娟

崔紅娟

崔紅娟,博士、西南大學蠶學與系統生物學研究所教授、博士生導師。首批重慶市“百名海外高層次人才集聚計畫”入選者,也是西南大學引進的首位“百人計畫”高層次創新人才,從事細胞生物學特別是幹細胞生物學領域科學研究及人才培養。

簡歷

1988-2000年在西南大學完成本科、碩士、博士學習。
2000-2001年,第四軍醫大學博士後,
2001-2005年,俄亥俄醫學院生化及腫瘤生物學助理研究員;
2005-2009年,俄亥俄醫學院生化及腫瘤生物學助理教授;
2009-2010年,美國克利夫蘭研究診所幹細胞生物學及再生醫學助理教授;
2010-2014 重慶市百人計畫,
2010-2014成為重慶市巴渝學者。
2010-至今,西南大學教授
在美國期間,先後主持和參與了NIH、美國癌症協會和俄亥俄州多項課題的研究。在Nature Cel. Bio.,J.Biol.Chem.,Am.J.Pathol.,Molcancer Ther.等國際著名雜誌發表高水平學術論文10餘篇。

主要科研領域與方向

腫瘤生物學及腫瘤幹細胞的研究;
家蠶、昆蟲幹細胞生物學發育及細胞生物學領域;
腫瘤藥效評價及轉化醫學。

代表性論文

Mao L, Ding J, Zha Y, Yang L, McCarthy B, King W, Hongjuan Cui, Ding H. HOXC9 links cell cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma. Cancer Res., 2011 inpress.Yang L, Hongjuan Cui, Wang Z, Zhang B, Ding J, Liu L, Ding HF. Loss of negative feedback control of nuclear factor-kappa B2 activity in lymphocytes leads to fatal lung inflammation. Am J pathol, 2010 Apr 2. Epib ahead of print.Yang H, Zhu L, Ebraheim NA, Liu X, Castillo S, Tang T, Liu J, Hongjuan Cui.2009, Analysis of risk factors for recurrence after the resection of sacral chordoma combined with embolization.Spine J. Sep30.Ling Mao, Yuan-Peng Xia, Yu-Nan Zhou, Ruo-Lian Dai, Xue Yang, Shu-Jie Duan, Xian Qiao, Yuan-Wu Mei, Bo Hu and Hongjuan Cui, 2009 Acritical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cellsCancer Sci.Jun 26. [Epub ahead of print]Goleeta Alam, Hongjuan Cui(co-principal author),Huilin Shi, Jane Ding, ling Mao, William A. Maltese, and Han-Fei Ding, MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development. Am J Pathol.2009 Aug; 175(2):856-66. Epub 2009 Jul 16.Huilin Shi, Hongjuan Cui, Goleeta Alam, William Gunning, Andrea Nestor, David Giovannucci, Ming Zhang, Han-Fei Ding, 2008. nestin expression defines both glial and neuronal progenitors in postnatal sympathetic Ganglia, Journal of Comparative Neurology, 508: 867-878.Hongjuan Cui, Bo Hu, Tai Li, Jun Ma, Goleeta Alam, William T Gunning, and Han-Fei Ding, 2007. Bmi-1 is essential for the tumorigenicity of Neuroblastoma cells, American Journal of Pathology, 170 (4): 1370-1378.Hongjuan Cui, Jun Ma, Jane Ding, Tai Li, Goleeta Alam, and Han-Fei Ding, 2006, Bmi-1 regulates differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner, Journal of Biological Chemistry, 281 (45): 34696-34704. Hongjuan Cui, Tai Li, Han-Fei Ding, 2005, Linking of N-Myc to death receptor machinery in neuroblastoma cells, Journal of Biological Chemistry, 280: 9474-9481Yongqing Wang, Hongjuan Cui (Co-principal author), Allen Schroering, Jane L. Ding, William S. lane, Gaël McGill, David E. Fisher and Han-Fei Ding. 2002. NF-ĸB2 p100 is a pro-apoptotic protein with anti-oncogenic function. Nature Cell Biology. 4(11): 888-93. Hongjuan Cui, Allen Schroering, and Han-Fei Ding. 2002. p53 mediated DNA damaging drug-induced apoptosis through a caspase-9-dependent pathway in Sh-SY5Y neuroblastoma cells. Molecular Cancer Therapeutics. 1: 679-686.

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