簡介
周海夢 博士
教授,博導
1970年,清華大學工程化學系 本科
1981年,清華大學套用化學 碩士
1986年,中國科學院生物物理所 博士
1990年至今 清華大學生命科學學院(原生物科學與技術系) 教授
現任浙江清華長三角研究院浙江省套用酶學重點實驗室主任
研究領域
主要科研領域與方向:主要研究方向為酶的結構與功能研究。包括酶的化學修飾、酶的催化動力學、酶結構改變對生物活性的影響等。目前集中於蛋白質摺疊的研究,包括蛋白質摺疊中間體、摺疊途徑等研究。
Selected Publications:
■ Zhao TJ, Ou WB, Xie Q, Liu Y, Yan YB* & Zhou HM*. 2005. Catalysis of creatine kinase refolding by protein disulfide isomerase involves disulfide cross-link and dimer to tetramer switch. J Biol Chem. 280(14):13470-13476.
■ Meng FG, Hong YK, He HW, Lyubarev AE, Kurganov BI, Yan YB* & Zhou HM*. 2004. Osmophobic effect of glycerol on irreversible thermal denaturation of rabbit creatine kinase. Biophys J. 87:2247-2254.
■ Pan JC, Yu Z, Su XY, Sun YQ, Rao XM & Zhou HM*.2004. Unassisted refolding of urea-denatured arginine kinase from shrimp Feneropenaeus chinensis: evidence for two equilibrium intermediates in the refolding pathway. Protein Sci. 13:1892-1901.
■ Meng FG, Park YD& Zhou HM*. Role of proline, glycine, and heparin sodium as protein folding aids during refolding of rabbit muscle creatine kinase. Int. J. Biochem. Cell Biol. 33:701-709.
■ Ou WB, Luo W, Park YD & Zhou HM*. 2001. Chaperone-like activity of peptidyl-prolyl cis-trans isomerase during creatine kinase refolding. Protein Sci. 10:2346-2353.
■ Ou WB, Park YD & Zhou HM*. 2001. Molecular mechanism for osmolytes protection of creatine kinase against guanidine denaturation. Eur. J. Biochem. 268:5901-5911.