吳瑛[中科院生物物理所研究員]:吳瑛：中科院生物物理所腦與認知科學國家重 -百科知識中文網

學習經歷

1980-1986年上海醫科大學醫學士

1986-1991年美國史丹福大學腫瘤生物學博士

1991-1994年哈佛大學生物化學和分子生物學系博士後

參考資料

工作經歷

1994年起任華盛頓大學兒科系和分子生物與藥理學系助理教授分子遺傳學、分子細胞生物、發育生物學等學科博士生導師

1998年起兼上海醫科大學教授

2001年起參與中國科學院上海生命科學研究院分子生物學研究生課程教學，後升副教授並獲終身教職

2003-2005 美國Vanderbilt大學，教授

2005-2008 美國西北大學醫學院，Lurie 癌症中心，Charles Luis Mix 教授

2008-至今中國科學院生物物理研究所，高級顧問研究員

參考資料

研究領域

研究方向

吳瑛研究員所在課題組主要研究參與神經發育和神經推行性病變的基因調控的分子機制

具體研究內容

1）RNA調控

2）細胞遷移的分子機制

擔任職務

為Science、Nature、Cell、MCB、PNAS等15個雜誌審稿，為美國國立健康研究院、老年痴呆基金會、加拿大醫學研究委員會、義大利Telethon基金會等評審基金。在哈佛大學參與生物化學教學、在華盛頓大學參與核酸與蛋白質、細胞生物學博士生課程教學, 在英國劍橋、美國哈佛大學、賓州大學、布朗大學等做過學術報告。

現任美國西北大學講座教授，清華大學長江講座教授，中國科學院生物物理研究所研究員。吳瑛以研究RNA剪接的分子生物學著名。曾獲中國國家自然科學基金委員會“國家傑出青年基金”B類。

學術成果

論文發表於Cell、Nature、Science、MCB、J.Neuroscience,、JBC。曾獲美國白血病學會連續十二年資助(從博士後、特別研究員到學者獎)

發表論文

Göhrig A, Detjen KM, Hilfenhaus G, Körner J, Arsenic R, Welzel M, Schmuck R, Bahra M, Wu JY, Wiedenmann B, Fischer C(2014). The Axon Guidance Factor Slit2 inhibits Pancreatic Cancer Metastasis and Cell Movement along Neurites. Cancer Res.74(5):1529-40

Li Y, Yang M, Huang Z, Chen X, Maloney M, Zhu L, Liu J, Yang Y, Du S, Jiang X,Wu JY.(2014) AxonQuant: a microfluidic chamber culture-coupled algorithm that allows high-throughput quantification of axonal damage. NeuroSignalsFeb28.

RNA and Cancer. Wu JY (ed.) ISBN 978-3-642-316586; Library of Congress Control Number 2012946188 (Springer, 2013) [book summary]

POST-TRANSCRIPTIONAL GENE REGULATION-RNA PROCESSING IN EUKARYOTES. Wu JY (ed.) ISBN 978-3527322022 (Wiley-Blackwell, 2013) [book summary]

Bigio EH,Wu JY, Deng HX, Bit-Ivan EN, Mao Q, Ganti R, Peterson M, Siddique N, Geula C, Siddique T, Mesulam M.(2013) Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid. Acta Neuropathol. 125(3):463-5.

Xu M, Zhu L, Liu J, Yang Y,Wu JY, Wang C(2013) Characterization ofβ-domains in C-terminal fragments of TDP-43 by scanning tunneling microscopy. J Struct Biol.181(1):11-6.

Chen Q, Sun X, Zhou XH, Liu JH,Wu J, Zhang Y, Wang JH(2013) N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors.J Cell Sci. 126:186-95.

Zhu K, Chen XP, Liu JH, Ye Hh, Zhu L,Wu JY(2013) AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth. Protein Cell4 (2): 155–161.

Chen Y, Yang M, Deng J, Chen X, Ye Y, Zhu L, Liu J, Ye H, Shen Y, Li Y, Rao EJ, Fushimi K, Zhou X, Bigio EH, Mesulam M,Wu JY.(2011) Expression of human FUS protein in Drosophila leads to progressive neurodegeneration. Protein Cell2(6):477–486.

Ray P, Kar A, Fushimi K, Havlioglu N, Chen X,Wu JY(2011) PSF Suppresses Tau Exon 10 Inclusion by Interacting with a Stem-Loop Structure Downstream of Exon 10.J Mol Neurosci.45(3):453-66.

Xu Y, Ye H, Shen Y, Xu Q, Zhu L, Liu J, Wu JY.(2011) Dscam mutation leads to hydrocephalus and decreased motor function.Protein Cell.2(8):647-55.

Yu B, Fey P, Kestin-Pilcher KE, Fedorov A, Prakash A, Chisholm RL, Wu JY.(2011) Spliceosomal genes in the D. discoideum genome: a comparison with those in H. sapiens, D. melanogaster, A. thaliana and S. cerevisiae.Protein Cell.2(5):395-409.

Guo W, Chen Y, Zhou X, Kar A, Ray P, Chen X, Rao EJ, Yang M, Ye H, Zhu L, Liu J, Xu M, Yang Y, Wang C, Zhang D, Bigio EH, Mesulam M, Shen Y, Xu Q, Fushimi K, Wu JY.(2011) An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity.Nat Struct Mol Biol.18(7):822-30.

Kar A, Fushimi K, Zhou X, Ray P, Shi C, Chen X, Liu Z, Chen S, Wu JY.(2011) RNA Helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site.Mol Cell Biol.31(9):1812-21.

Fushimi K, Long C, Jayaram N, Chen X, Li L, Wu JY.(2011) Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy.Protein Cell.2(2):141-9.

Dunaway CM, Hwang Y, Lindsley CW, Cook RS, Wu JY, Boothby M, Chen J, Brantley-Sieders DM.(2011) Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis.Mol Cell Biol.31(3):404-16.

Brantley-Sieders DM, Dunaway CM, Rao M, Short S, Hwang Y, Gao Y, Li D, Jiang A, Shyr Y, Wu JY, Chen J.(2011) Angiocrine Factors Modulate Tumor Proliferation and Motility through EphA2 Repression of Slit2 Tumor Suppressor Function in Endothelium.Cancer Res.71(3):976-987.

Gao X, Joselin AP, Wang L, Kar A, Ray P, Bateman A, Goate AM, Wu JY.(2010) Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.Protein Cell.1(6):552-62.

Guo W, Li JT, Pan X, Wei L, Wu JY.(2010) Candidate Mycobacterium tuberculosis genes targeted by human microRNAs.Protein Cell.1(5):419-21.

Kaneko N, Marín O, Koike M, Hirota Y, Uchiyama Y, Wu JY, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein JL, Sawamoto K.(2010) New neurons clear the path of astrocytic processes for their rapid migration in the adult brain.Neuron.67(2):213-23.

Yu J, Cao Q, Yu J, Wu L, Dallol A, Li J, Chen G, Grasso C, Cao X, Lonigro RJ, Varambally S, Mehra R, Palanisamy N, Wu JY, Latif F, Chinnaiyan AM.(2010) The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer.Oncogene.29(39):5370-80.

Ray P, Luo XY, Rao EJ, Basha A, Woodruff EA, Wu JY.(2010) The splicing factor Prp31 is essential for photoreceptor development in Drosophila.Protein Cell1(3):267-274.

吳瑛[中科院生物物理所研究員]

基本信息