![劉中秋[廣州中醫藥大學教授]](/img/9/73b/nBnauM3X3UDMyMTO5UjM1IzN0QTMwITOzEDMwADMwAjMwIzL1IzLyAzLt92YucmbvRWdo5Cd0FmLzE2LvoDc0RHa.jpg "劉中秋[廣州中醫藥大學教授]")
中秋教授現任廣州中醫藥大學國際中醫藥轉化醫學研究所所長。於香港浸會大學獲得中藥學博士學位，並在香港浸會大學從事博士後研究工作。劉中秋教授曾在美國休斯頓大學藥學院作訪問學者，擔任南方醫科大學藥學院分子藥劑系教授，分子藥劑學學科主任和藥學院副院長。
同時，劉中秋教授是973計畫項目"確有療效的有毒中藥科學套用關鍵問題的基礎研究"項目專家組成員，兼任國家自然科學基金同行評議專家，中國藥理學會藥物代謝委員會（CSSX） ，美國藥學學會會員(AAPS)，美國化學學會會員(ACS)和英國藥理學會會員（BPS）。此外，劉教授是世界中醫藥學會聯合會中藥藥劑學專業委員會常務理事、中華中醫藥學會專業委員會常務理事，廣東省高等學校"千百十工程"國家級培養對象。
劉中秋教授研究領域為藥代動力學，主要研究方向為中藥藥代動力學中影響中藥藥效和毒性的生物學因素及機理，從而評價中藥活性/毒性成分的ADME/T成藥性質。劉教授先後主持各類科研基金18項，其中國家級重點項目4項，參加美國NIH課題1項，在國際學術刊物上共發表SCI論文50多篇。還擔任Molecular Pharmaceutics，Current Drug Metabolism，International Journal of Pharmaceutics，Journal of Pharmaceutical Sciences，PLoS One，Life Sciences 等國際期刊特邀審稿員。
研究方向
● 影響藥物生物利用度的生理屏障及機理研究
● 基於藥物吸收與代謝原理的新型給藥傳遞系統研究
發表論文
[1] Ye L, Shi J, Wan S, Yang X, Wang Y, Zhang J,Zheng D, Liu ZQ*. Development andvalidation of a liquid chromatography-tandem mass spectrometry method fortopotecan determination in beagle dog plasma and its application in abioequivalence study. Biomed Chromatogr. 2013 Nov;27(11):1532-9.
[2] Tang L, Li Y, Chen WY, Zeng S, Dong LN, PengXJ, Jiang W, Hu M, Liu ZQ*. BreastCancer Resistance Protein-Mediated Efflux of Luteolin Glucuronides in HeLa CellsOverexpressing UDP-Glucuronosyltransferase 1A9. Pharm Res. 2013 Oct 3. [Epubahead of print]
[3] Tang L, Dong LN, Peng XJ, Li Y, Shi J, ZhouFY, Liu ZQ*. Pharmacokineticcharacterization of oxymatrine and matrine in rats after oral administration ofradix Sophorae tonkinensis extract and oxymatrine by sensitive and robustUPLC-MS/MS method. J Pharm Biomed Anal. 2013 Sep;83:179-85.
[4] Ye L, Lu L, Li Y, Zeng S, Yang X, Chen W, FengQ, Liu W, Tang L, Liu ZQ*. Potentialrole of ATP-binding cassette transporters in the intestinal transport of rhein.Food Chem Toxicol. 2013 Aug;58:301-5.
[5] Cai Z, Huang J, Luo H, Lei X, Yang Z, Mai Y, Liu ZQ*. Role of glucose transporters inthe intestinal absorption of gastrodin, a highly water-soluble drug with goodoral bioavailability. J Drug Target. 2013 Jul;21(6):574-80.
[6] Ye L, Yang XS, Lu LL, Yan TM, Dong LN, PengXJ, Shi J, Liu ZQ*.Monoester-diterpene aconitum alkaloids metabolism in human liver microsomes:predominant role of CYP3A4 and CYP3A5. Evid Based Complement Alternat Med.2013;2013:941093.
[7] Ye L, Yang X, Yang Z, Gao S, Yin T, Liu W,Wang F, Hu M, Liu ZQ*. The role ofefflux transporters on the transport of highly toxic aconitine, mesaconitine,hypaconitine, and their hydrolysates, as determined in cultured Caco-2 andtransfected MDCKII cells. Toxicol Lett. 2013 Feb 4;216(2-3):86-99.
[8] Zhu L, Yang X, Zhou J, Tang L, Xia B, Hu M,Zhou F, Liu ZQ*.The exposure ofhighly toxic aconitine does not significantly impact the activity andexpression of cytochrome P450 3A in rats determined by a novel ultraperformance liquid chromatography-tandem mass spectrometric method of aspecific probe buspirone. Food Chem Toxicol. 2013 Jan;51:396-403.
[9] Xia B, Zhou Q, Zheng Z, Ye L, Hu M, Liu ZQ*. A novel local recycling mechanismthat enhances enteric bioavailability of flavonoids and prolongs theirresidence time in the gut. Mol Pharm. 2012 Nov 5;9(11):3246-58.
[10] Liu W, Feng Q, Li Y, Ye L, Hu M, Liu ZQ*. Coupling ofUDP-glucuronosyltransferases and multidrug resistance-associated proteins isresponsible for the intestinal disposition and poor bioavailability of emodin.Toxicol Appl Pharmacol. 2012 Dec 15;265(3):316-24.
