任濤[同濟大學附屬東方醫院主任醫師]

任濤[同濟大學附屬東方醫院主任醫師]

任濤,男,漢族,國籍中國,同濟大學附屬東方醫院主任醫師;美國胸科學會會員(Member of American Thoracic Society);上海市醫學會呼吸病學專科分會第十屆委員會委員兼秘書(Member of Respiratory Diseases Society ,Shanghai Medical Association)

任濤,博士,教授,同濟大學附屬東方醫院呼吸內科主任醫師,同濟大學醫學院博士生導師。畢業於復旦大學。臨床專長:肺部腫瘤的早期診斷,孤立性肺結節的鑑別診斷,肺癌化療,肺癌靶向治療,肺癌免疫治療,抗腫瘤治療的輔助治療,COPD、哮喘、肺部感染與呼吸衰竭的診治。

入選上海市青年科技啟明星計畫及其追蹤計畫,上海中西醫結合學會呼吸專業委員會委員,第七屆上海醫學科技獎(三等獎)獲得者,擔任《國際內科學雜誌》、《藥學服務與研究》、《中國臨床藥學雜誌》、《臨床內科雜誌》編委,《African Health Sciences》審稿人,浦東新區科委專家庫成員,上海市科學技術專家庫成員,國家自然科學基金評議人。中共東方醫院內系二支部書記,呼吸內科主任,肺部腫瘤專科主任,美國胸科學會會員(Member ofAmerican Thoracic Society)。

科研方向為肺癌的增殖、侵襲與轉移的信號機制及其調控。先後承擔國家自然科學基金、上海市自然科學基金、上海市科委和上海市衛生局課題、浦東新區科委課題、浦東新區衛生局課題以及同濟大學課題10餘項。發表文章近50篇,其中以第一作者或通訊作者發表SCI收錄論著5篇,累計影響因子11.87。獨立和協助指導碩士和博士研究生8名。

主要科研成績:

1、科研論著(Research Publications)

(1)Zhang X, Wang C, Shan S, Liu X, Jiang Z, Ren T (通訊). TLR4/ROS/miRNA-21 pathway

underlies lipopolysaccharide instructed primary tumor outgrowth in lung cancer patients. Oncotarget. 2016 Jun 7. doi: 10.18632/oncotarget.9902. [Epub ahead of print].

(2)Li Q, Han Y, Wang C, Shan S, Wang Y, Zhang J, Ren T (通訊). MicroRNA-125b promotes tumor metastasis through targeting tumor protein 53-induced nuclear protein 1 in patients with non-small-cell lung cancer. Cancer Cell Int. 2015 Sep 17;15:84.

(3)Zhang W, Zhu D, Tian D, Xu L, Zhu Z, Teng Z, He J, Shan S, Liu Y, Wang W, Yuan Z, Ren T(共同通訊), Hu Y. Co-infection with Avian (H7N9) and Pandemic (H1N1) 2009 Influenza Viruses, China. Emerg Infect Dis. 2015 Apr;21(4):715-8.

(4)Guo Z, Gu Y, Wang C, Zhang J, Shan S, Gu X, Wang K, Han Y, Ren T(通訊). Enforced expression of miR-125b attenuates LPS-induced acute lung injury. Immunol Lett.2014 Nov;162(1 Pt A):18-26.

(5)Xu Z, Wu F, Wang C, Liu X, Kang B, Shan S, Gu X, Wang K, Ren T(通訊). The stimulatory activity of plasma in patients with advanced non-small cell lung cancer requires TLR-stimulating nucleic acid immunoglobulin complexes and discriminates responsiveness to chemotherapy. Cancer Cell Int. 2014 Aug 12;14:80.

(6)Lin R, Ren T(並列一作), Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013 Aug 22;51(4):506-18.

(7)Guo Z, Wen Z, Qin A, Zhou Y, Liao Z, Liu Z, Liang Y, Ren T(共同通訊), Xu L. Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells. J Immunol. 2013 Apr 15;190(8):4337-48.

(8) Qin A, Wen Z, Zhou Y, Li Y, Li Y, Luo J, Ren T(共同通訊), Xu L. MicroRNA-126 regulates the induction and function of CD4(+) Foxp3(+) regulatory T cells through PI3K/AKT pathway. J Cell Mol Med. 2013 Feb;17(2):252-64.

(9) Xu L, Wen Z, Zhou Y, Liu Z, Li Q, Fei G, Luo J, Ren T(通訊). MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway. Mol Biol Cell. 2013 Jan;24(1):42-55.

(10)Li Q, Li X, Guo Z, Xu F, Xia J, Liu Z, Ren T Ren T(通訊). MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer. PLoS One. 2012;7(11):e48278.

(11) Li Q, Han Y, Fei G, Guo Z, Ren T(共同通訊), Liu Z. IL-17 promoted metastasis of non-small-cell lung cancer cells. Immunol Lett. 2012 Dec 17;148(2):144-50.

(12) Guo Z, Li Q, Han Y, Liang Y, Xu Z, Ren T(通訊). Prevention of LPS-induced acute lung injury in mice by progranulin. Mediators Inflamm. 2012;2012:540794.

(13)Wang C, Fei G, Liu Z, Li Q, Xu Z, Ren T(通訊). HMGB1 was a pivotal synergistic effecor for CpG oligonucleotide to enhance the progression of human lung cancer cells. Cancer Biol Ther. 2012 Jul;13(9):727-36.

2、科研課題(Grant support)

(1)靶向抑制PP2A與肺鱗癌細胞的乾性逆轉與化療增敏研究,國家自然科學基金面上項目,2017.1-2020.12

(2)TLR9對肺腺癌幹細胞的乾性維持作用及其機制研究,上海市優秀學術帶頭人計畫附帶課題,2016.1-2018.12

(3)NSCLC癌幹細胞TLR9的表達特點、信號級聯與乾性維持作用,國家自然科學基金面上項目,2014.1-2017.12

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