高春梅[清華大學副研究員]

個人資料

高春梅， 清華大學副研究員，主要從事天然產物的結構改造和構效關係研究 。

研究方向

主要從事抗腫瘤細胞小分子化合物的設計、合成及活性研究，具體研究方向如下：

1. 以DNA及DNA相關酶(拓撲異構酶、DNA修復酶)為靶點的化合物的設計、合成及活性研究;

2. 基於Pokemon信號傳導通路的抗腫瘤化合物的設計與合成;

3. 基於計算機輔助的高通量篩選系統的抗腫瘤藥物研發;

4. 表觀遺傳與抗腫瘤藥物研發。

個人作品

1. Bin Zhang, Xi Li, Bin Li, Chunmei Gao*, Yuyang Jiang* Acridine and its derivatives: a patent review (2009-2013), Expert Opinion On Therapeutic Patents 2014 (in press)

2. Bin Li, Chunmei Gao*, Qinsheng Sun, Lulu Li, Chunyan Tan, Hongxia Liu, Yuyang Jiang* Novel Synthetic, Acridine-based Derivatives as Topoisomerase I Inhibitors, Chinese Chemical Letters 2014 (in press).

3. Xuliang Lang, Lulu, Li., Yuzong Chen, Qinsheng Sun, Qin Wu, Feng Liu, Chunyan Tan, Hongxia Liu, Chunmei Gao*, and Yuyang Jiang* Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents, Bioorganic & Medcinal Chemistry 2013, 21, 4170-4177.

4. Xuliang Lang, Qinsheng Sun, Yuzong Chen, Li, L.-L., Chunyan Tan, Hongxia Liu, Chunmei Gao*, and Yuyang Jiang* Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase I inhibitor, Chinese Chemical Letters 2013, 24, 677-680.

5. Yini Wang, Dan Gao, Zhe Chen , Shangfu Li, Chunmei Gao, Deliang Cao, Feng Liu, Hongxia Liu, and Yuyang Jiang*, Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents, Plos One 2013, 8, e63572.

6. Jinshun Lin, Xinli Jin, Yiwen Bu, Deliang Cao, Nannan Zhang, Shangfu Li, Qinsheng Sun, Chunyan Tan, Chunmei Gao*, and Yuyang Jiang*, Efficient synthesis of RITA and its analogues: derivation of analogues with improved antiproliferative activity via modulation of p53/miR-34a pathway, Organic & Biomolecular Chemistry 2012, 10, 9734-9746.

7. Chunmei Gao*, Shangfu Li, Xuliang Lang, Hongxia Liu, Feng Liu, Chunyan Tan, and Yuyang Jiang*, Synthesis and evaluation of 10-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as selective telomeric G-quadruplex DNA ligands, Tetrahedron 68, 7920-7925, 2012.

8. Xuliang Lang, Xudong Luan, Chunmei Gao* and Yuyang Jiang*, Recent Progress of Acridine Derivatives with Antitumor Activity, Progress in Chemistry 2012, 24, 1497-1505.

9. Yibao Jin, Xudong Luan, Hongxia Liu, Chunmei Gao, Shangfu Li, Deliang Cao, Xiaoyan Li, Zongwei Cai and Yuyang Jiang*, Pharmacokinetics and metabolite identification of a novel VEGFR-2 and Src dual inhibitor 6-chloro-2-methoxy-N-(2-methoxybenzyl) acridin-9-amine in rats by liquid chromatography tandem mass spectrometry, Talanta2012, 89, 70-76.

10. Lei Wang, Guangming Zhu, Junqin Li and Chunmei Gao*, Synthesis and characterization of partially fluorinated poly(fluorenyl ether ketone)s with different degrees of sulfonation as proton exchange membranes, Polymer Bulletin 2011, 66, 925-937.

11. Xudong Luan, Chunmei Gao, Nannan Zhang, Yuzong Chen, Qinsheng Sun, Chunyan Tan, Hongxia Liu, Yibao Jin, and Yuyang Jiang*, Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors, Bioorganic & Medcinal Chemistry 2011, 19, 3312-3319.

12. Xudong Luan, Chunmei Gao, Qinsheng Sun, Chunyan Tan, Hongxia Liu, Yibao Jin and Yuyang Jiang*, Novel Synthetic Azaacridine Analogues as Topoisomerase 1 Inhibitors, Chemistry Letters 2011, 40, 728-729.

13. Xiangming Hu, Chunmei Gao, Chunyan Tan, Cunlong Zhang, Hualin Zhang, Shangfu Li, Hongxia Liu and Yuyang Jiang*, Design and Synthesis of N-phosphoryl Peptide Modified Podophyllotoxin Derivatives as Potent Anticancer Agents, Protein & Peptide Letters 2011, 18, 1258-1264.

14. Yunqi Li, Chunyan Tan, Chunmei Gao, Cunlong Zhang, Xudong Luan, Xiaowu Chen, Hongxia Liu, Yuzong Chen and Yuyang Jiang*, Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors, Bioorganic & Medcinal Chemistry 2011, 19, 4529-4535.

15. Chunmei Gao, Feng Liu, Xudong Luan, Chunyan Tan, Hongxia Liu, Yonghua Xie, Yibao Jin and Yuyang Jiang*, Novel synthetic 2-amino- 10-(3,5-dimethoxy)benzyl-9(10H)-acridinone derivatives as potent DNA-binding antiproliferative agents, Bioorganic & Medcinal Chemistry 2010, 18, 7507-7514.

16. Huachen Liu, Aijun Dong, Chunmei Gao, Chunyan Tan, Zhenhua Xie, Xuyu Zu, Long Qu and Yuyang Jiang*, New synthetic flavone derivatives induce apoptosis of hepatocarcinoma cells, Bioorganic & Medcinal Chemistry 2010, 18, 6322-6328.

17. WenJie Liu, Derong Cao*,. Chunmei Gao, Yuyang Jiang, and Meier, H. Synthesis of Fr,chet-type dendritic homotriptycenes, Sci China Ser B 2009, 52, 1051-1056.

18. Huachen Liu, Aijun Dong, Chunmei Gao, and Yuyang Jiang* Structure Modification of Resveratrol and Pharmacological Activity, Prog Chem 2009, 21, 1500-1506.

19. Huachen Liu, Aijun Dong, Chunmei Gao, Chunyan Tan, Hongxia Liu, Xuyu Zu, and Yuyang Jiang* The design, synthesis, and anti-tumor mechanism study of N-phosphoryl amino acid modified resveratrol analogues, Bioorganic & Medcinal Chemistry 2008, 16, 10013-10021.

20. Chunmei Gao, Huachen Liu, Yuyang Jiang*, Chunyan Tan, and Derong Cao*, Synthesis of 10-Benzyl-9-acridone and Its Reduction with NaBH4, Chinese J Org Chem 2008, 28, 1803-1806.

21. Chunmei Gao, Yuyang Jiang*, Chunyan Tan, Xuyu Zu, Huachen Liu, and Derong Cao*, (2008) Synthesis and potent antileukemic activities of 10-benzyl-9(10H)-acridinones, Bioorganic & Medcinal Chemistry 2008, 16, 8670-8675.

22. Lei Wang, Guangming Zhu, Yuezhong Meng, and Chunmei Gao Synthesis and properties of sulfonated poly(arylene ether) containing triphenyl methane moieties from isocynate masked bisphenol, Chinese Journal of Polymer Science 2007, 25, 419-426.

23. Lei Wang, Yuezhong Meng, Chunmei Gao, and Guangming Zhu Synthesis and properties of sulfonated poly(arylene ether) for proton exchange membrane, Acta Chim Sinica 2007, 65, 1403-1406.

24. Dobis, S., Schollmeyer, D., Chunmei Gao, Derong Cao,, and Meier, H. Structure determination of photoproducts of anthracenes with (arylmethoxymethyl) sidechains, Eur J Org Chem, 2007, 2964-2969.

25. Derong Cao, Chunmei Gao, Dobis, S., and Meier, H. Competition between inter- and intramolecular photocycloaddition reactions of 9-substituted anthracenes, Synthesis-Stuttgart, 2007, 1995-2001.

26. Derong Cao, Dobis, S., Chunmei Gao, Hillmann, S., and Meier, H. Optical switching and antenna effect of dendrimers with an anthracene core, Chem-Eur J 2007, 13, 9317-9323.

27. Lei Zhu, Derong Cao, and Chunmei Gao Monoetherification of 9,10-bishydroxymethylanthracene, Chinese J Org Chem 2006, 26, 848-851.

28. Chunmei Gao, Derong Cao, Sheyang Xu, and Meier, Herbert Acid-catalyzed cyclization of anthracenol derivatives to homotriptycenes, J Org Chem 2006, 71, 3071-3076.

29. Chunmei Gao, Derong Cao, and Sheyang, Xu. Acid-catalyzed selective cyclization of 10,10-dibenzyl-9(10H)-anthranol, Acta Chim Sinica 2006, 64, 1757-1760.

30. Derong Cao, Sheyang, Xu, Chunmei Gao and Meier, H. Protonation and rearrangement of the tricyclo[4.2.2.2(2,5)]dodeca-3,7,9,11-tetraene scaffold, Tetrahedron Lett 2006, 47, 2759-2763.

31. 蔣宇揚，郎許亮，高春梅，孫欽升，吖啶衍生物及其製備方法和用途，中國，201310169132.2

32. 蔣宇揚, 李彬, 高春梅, 苯並咪唑吖啶類化合物的製備方法與套用，中國，201410095626.5。

33. 蔣宇揚，欒旭東，高春梅，譚春燕，劉紅霞，金一寶 9-苯胺基吖啶衍生

物及其製備方法與套用，中國，201110020165.1

34. 蔣宇揚，高春梅，劉峰，欒旭東，譚春燕，劉紅霞N-苄基-吖啶酮及其

衍生物以及它們的製備方法與套用， 中國，201010110870.6

35. 蔣宇揚，高春梅，劉華臣 磷醯化胺基酸二苯乙烯衍生物及其製備方法與

套用，中國，2011.12，200810104213.3