人物經歷
1999年於德國海德堡大學獲得博士學位,1999-2004年先後在德國國家癌症研究中心、哈佛大學醫學院從事遺傳與發育生物學專業博士後訓練與研究。現為美國遺傳學會、美國發育生物學學會會員、中國細胞生物學學會第九、十屆理事會理事(2007-2015)、中國細胞生物學學報第一屆編委(2010-2014)、《Cell Research》、《Molecular and Cellular Biochemistry》等SCI期刊審稿人。
研究方向
以果蠅為模式生物體,研究相關發育過程的遺傳控制以及表觀遺傳調節機理。實驗室目前在下列兩個研究領域開展工作:
1.幹細胞及相關細胞譜系發育的調控:研究性腺發育與卵子發生中,生殖幹細胞、成體幹細胞及兩大細胞譜系-生殖細胞和濾泡細胞的發育調控機理,涉及幹細胞的自我更新/分化、幹細胞與微環境的相互作用,濾泡上皮組織的體軸模式建成/形態發生等。致力於發現和鑑定重要功能基因、表觀遺傳調控因子等。
2.JNK信號通路及其調控:篩選JNK信號通路新的調節因子/效應分子,並功能性鑑定該調節作用在相關發育過程中的意義。
主要貢獻
發表論文
1. Li, Q., Feng, S., Yu, L., Zhao,G., Li, M*. Requirements of Lgl in cell differentiation and motility during Drosophila ovarian follicular epithelium morphogenesis. Fly (Austin), 2011, 5: 81-87。
2. Zhu, M., Xin, T., Weng, S., Gao, Y., Zhang, Y., Li, Q., Li, M* . Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs. Cell Research, 2010, 20: 242-245。
3. Li, Q., Shen, L., Xin, T., Xiang, W., Chen, W., Gao, Y., Zhu, M., Yu, L and Li, M*. Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis. BMC Developmental Biology. 2009, 9: 60 (1-15)。
4. Miles, WO., Jaffray, E., Campbell, SG., Takeda, S., Bayston, LG., Basu, SP., Li, M., Raftery, LA., Ashe, MP., Hay, RT., and Ashe, HL. Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo. Genes & Development. 2008, 22(18): 2578-2590。
5. Li, Q., Xin, T., Chen, W., Zhu, M., and Li, M﹡. Lethal(2)giant larvae is required in the follicle cells for formation of the initial AP asymmetry and the oocyte polarity during Drosophila oogenesis. Cell Research. 2008,18:372-384. (This paper is the cover story on the issue)。
6. Alone, DP., Tiwari, AK., Mandal, L., Li, M., Mechler, BM, and Roy, JK. Rab 11 is required during Drosophila eye development. International Journal of Developmental Biology. 2005, 49:873-79。
7. Sutherland, DJ., Li, M., Liu, X., Stefancsik, R., and Raftery, LA. Stepwise formation of a Smad activity gradient during dorsal-ventral patterning of the Drosophila embryo. Development. 2003, 130: 5705-5716。
8. Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, BM., Delins, H., Hoppe, D., Stannek, P., Glink, A., and Niehrs, C. Kremens are novel Dickkopf receptors that regulate Wnt signaling. Nature. 2002, 417; 664-667。
9. Li, M., Marhold, J., Gato, A., Toeroek, I., and Mechler, BM. Differential expression of two scribble isoforms during Drosophila embryogenesis. Mechanisms of Development. 2001, 108:185-190。
10. Li, M., Strand, D., Krehan, A., Pyerin, W., Neumann, B., and Mechler, BM. Casein kinase 2 binds and phosphorylates the nucleosome assembly protein-1 (NAP1) in Drosophila melanogaster. Journal of Molecular Biology. 1999, 293:1067-1084。
研究成果
1.獲省部級科技進步獎三項(1992,1994,1995,均為第三完成人)。
2.2005年入選首屆“上海市浦江人才計畫”。
3.主持完成國家自然科學基金課題兩項(編號:30470890,30871409);在研主持國家自然科學基金課題兩項(編號:31071289,31171426)。
4.承擔科技部重大科學研究計畫課題(學術骨幹,2012-2016)。