徐明良[中國農業大學教授]:徐明良，男，1964年2月出生,浙江寧波人 -百科知識中文網

人物簡介

個人簡歷

1980年9月－1984年7月，浙江農業大學寧波分校，獲農學學士學位。
1984年9月－1987年7月，原江蘇農學院，獲農學碩士學位。
1987年7月－2003年9月，揚州大學，助教、講師、副教授、教授、博士生導師
1993年9月－1996年7月，復旦大學，獲理學博士學位
1997年2月－1999年2月，德國Hohenheim大學，博士後
1999年2月－2002年6月，美國Illinois大學，博士後
2003年－－中國農業大學，教授，博士生導師。

教學工作

1、《玉米分子育種》分四講：1）分子標記；2）原理與套用；3）莖腐病；2）絲黑穗病及其它。

2、《功能基因組學》

研究方向

1. 挖掘和驗證玉米主要病害的抗性QTL

2. 闡明QTL調節的宿主病原互作的抗性機制

3. 證實抗病QTL的進化途徑

4. 改善玉米抗病性的分子育種

主要成就

1、科技部‘十三五’重點專項首席科學家。

2、完成和主持國家傑出青年基金、重大國際合作，科技部‘863’、‘973’計畫，農業部轉基因專項等多個國家級項目。在Nature Genetics、PNAS、Plant Cell等主流雜誌發表論文50多篇。

3、受聘於SCI收錄雜誌《Theoretical and Applied Genetics》、《Plant Molecular Biology Reporter》、《Journal of Genetics and Genomics》編委，《作物學報》副主編。

4、2006年獲國家傑出青年基金；2009年入選新世紀百千萬國家級人才工程，享受國務院特殊津貼；2011年榮獲全國百篇優秀博士論文指導教師。

5、長期來從事玉米等作物的功能基因組學與分子生物學研究。在玉米全基因組範圍內篩選出了抗病和防禦相關的候選基因300多個，並將他們定位到玉米基因組上，這一工作的完成為玉米各種抗病基因的克隆提供了材料、信息和技術平台；發展了一套全新的分離玉米Mu突變體旁鄰序列方法，為玉米功能基因大規模克隆奠定了基礎；克隆了玉米抗甘蔗花葉病毒病候選基因，已獲得轉基因植株，開展功能互補鑑定；完成抗青枯病、絲黑穗病基因的定位和基因區域高密度分子標記的發展，克隆候選基因，開展功能互補鑑定；構建了玉米抗病自交系FAP1360、1145等的BAC庫。

出版著作

Leng P, Ji Q, Tao Y, Ibrahim R, Pan G,Xu ML, Lübberstedt T.Characterization of sugarcane mosaic virus Scmv1 and Scmv2 resistance regions by regional association analysis in maize.PLoS One 2015, Doi: 10.1371/journal.pone.0140617. eCollection 201

Zuo WL, Chao Q, Zhang N, Ye JR, Tan GQ, Li BL, Xing YX, Zhang BQ, Liu HJ, Fengler KA, Zhao J, Zhao XR, Chen YS, Lai JS, Yan JB,Xu ML. A maize wall-associated kinase confers quantitative resistance to head smut. Nature Genetics, 2014, doi:10.1038/ng.3170

Konlasuk S, Xing YX, Zhang N, Zuo WL, Zhang BQ, Tan GQ,Xu ML.ZmWAK, a quantitative resistance gene to head smut in maize, improves yield performance by reducing the endophytic pathogen Sporisorium reiliana. Molecular Breeding 2015, 35:1-10.

4. Ye JR, Guo YL, Zhang DF, Zhang N, Wang C,Xu ML.Cytological and Molecular Characterization of QTL-qRfg1 Which Confers Resistance to Gibberella Stalk-Rot Disease in Maize. Mol. Plant-Microbe Interact. 2013, 26:1417-1428.

5. Qin Yang, Li Z, Li WQ, Ku LX, Wang C, Ye JR, Li K, Yang N, Li YP, Zhong T, Li JS, Chen YH, Yan JB, Yang XH,Xu ML. CACTA-like transposable element in ZmCCT attenuated photoperiod sensitivity and accelerated the post-domestication spread of maize. Proc Natl Acad Sci. 2013, 110: 16969–16974

6. Qin Yang, Zhang DF,Xu ML. A Sequential Quantitative Trait Locus Fine-Mapping Strategy Using Recombinant-Derived Progeny. Journal of Integrative Plant Biology, 2012, 54: 228–237

7. Qing Ji, Jufei Lu, Qing Chao, Yan Zhang, Meijing Zhang, Minghong Gu,Mingliang Xu*. 2010. Two sequence alterations, a 136-bp InDel and an A/C polymorphic site, in the S5 locus are associated with compatibility of indica/japonica hybrid in rice. J. Genet. Genomics 37

8. Qin Yang, Guangming Yin, Yanling Guo, Dongfeng Zhang, Shaojiang Chen, Mingliang Xu*. 2010. A major QTL for resistance to Gibberella stalk rot in maize. Theor Appl Genet 121:673

9. Lai JS, Li RQ, Xu X, Jin WW,Xu ML, Zhao HN, Xiang ZK, Song WB, Ying K, Zhang M, Jiao YP, Ni PX, Zhang JG, Li D, Guo XS, Ye KX, Jian M, Wang B, Zheng HS, Liang HQ, Zhang XQ, Wang SC, Cheng SJ, Li JS, Fu Y, Springer NM, Yang HM, Wang JA, Dai JR, Schnable PS, and Wang J. Genome-wide patterns of genetic variation among elite maize inbred lines. Nature Genetics, 2010, 42:1027-1030. (共同第一作者)
10. Usarowska A, Dionisio G, Sarholz B, Piepho HP, Xu ML, Ingvardsen CR, Wenzel G, Lübberstedt T. 2009. Validation of candidate genes putatively associated with resistance to SCMV and MDMV in maize (Zea mays L.) by expression profiling. BMC Plant Biology 2009, 9:15 doi:10.1186/1471-2229-9-15
11.Chen SH, Yang Y, Shi WW, Ji Q, He F, Zhang ZD, Cheng ZK, Liu XN, andXu ML. Badh2, encoding betaine aldehyde dehydrogenase, inhibits the biosynthesis of 2-acetyl-1-pyrroline, a major component in rice fragrance. Plant Cell, 2008, 20: 1850-1861
12. Soria-Guerra R,Xu ML, Korban S. 2008. Transgenic apple lines carrying vfa genes in tandem for resistance to apple scab. Hortscience 43:1156-1156.
13. Chen YS, Chao Q, Tan GQ, Zhao J, Zhang MJ, Ji Q, and Xu ML*. 2008. Identification and fine-mapping of a major QTL conferring resistance against head smut in maize. Theor Appl Genet,117:1241.
14.. Chen JJ, Ding JH, Ouyang YD, Du HY, Yang JY, Cheng K, Zhao J, Qiu SQ, Zhang XL, Yao JL, Liu KD, Wang L, CG Xu, Li XH, Xue YB, Xia M, Ji Q, Lu JF,Xu ML, and Zhang QF. 2008. A tri-allelic system of S5 is a major regulator of the reproductive barrier and compatibility of indica-japonica hybrids in rice. Proc Natl Acad Sci 105: 11436-11441
15. Jiang L, Ingvardsen CR, Lubberstedt T,Xu ML*. 2008. The Pic19 NBS-LRR gene family members are closely linked to Scmv1, but not involved in maize resistance to sugarcane mosaic virus. Genome, 51:673-684.

16. Chen SH, Yang Y, Shi WW, Ji Q, He F, Zhang ZD, Cheng ZK, Liu XN, and Xu ML*. 2008. Badh2, encoding betaine aldehyde dehydrogenase, inhibits the biosynthesis of 2-acetyl-1-pyrroline, a major component in rice fragrance. Plant Cell 20: 1850-1861
17. Wen WE, Li GQ, He ZH, Yang WY, Xu ML, Xia XC. 2008. Development of an STS marker closely linked to Yr26 against wheat stripe rust using the resistance gene-analog polymorphism (RGAP) technique. Mol Breed 22:507-515
18. Wang YJ, Yin GM, Yang Q, Tang JH, Lu XM, Korban SS, Xu ML*. 2008. Identification and isolation of Mu-flanking fragments from maize. J of Genetics and Genomics 35: 207-213
19. Malnoy M, Xu ML, Borejsza-Wysocka E, Korban SS, and Aldwinckle HS. 2008. Two receptor-like genes, Vfa1 and Vfa2, confer resistance to the fungal pathogen Venturia inaequalis inciting apple scab disease. Mol Plant-Microbe Interact 21:448-458. (共同第一作者)
20. Shi WW, Yang Y, Chen SH, Xu ML*. 2008. Discovery of a new fragrance allele and the development of functional markers for the breeding of fragrant rice varieties. Mol Breed 22:185-192.
21. Xiao WK, Zhao J, Fan SC, Li L, Dai JR, Xu ML*. 2007. Mapping of genome-wide resistance gene analogs (RGAs) in maize (Zea mays L.). Theor Appl Genet. 115:501-508.
22. Wang GX, Chen Y, Zhao JR, Li L, Korban SS, Wang FG, Dai JR, Xu ML*. 2007. Mapping of defense response gene homologues and their association with resistance loci in maize. Journal of Integrative Plant Biology 49:1580-1598.
23. Han YP, Gasic K, Sun FJ, Xu ML, Korban SS. 2006. A gene encoding starching branching enzyme I (SBEI) in apple (Malus × domestica, Rosaceae) and its phylogenetic relationship to Sbe genes from other angiosperms. Molecular Phylogenetics and Evolution 43:852-863.
24. Farrar K, Asp T, Lübberstedt T, Xu ML, Christiansen C, Thomas A, Humphreys M, Donnison I. 2006. Construction and utilization of two Lolium perenne BAC libraries. Mol Breed. 19:15-23.
25. Chen SH, Wu J, Yang Y, Shi WW, Xu ML*. 2006. The fgr gene responsible for rice fragrance was restricted within 69kb. Plant Science 171：505-514.
26. Xiao WK, Xu ML*, Zhao JR, Wang FG, Li JS, Dai JR. 2006. Genome-wide isolation of resistance gene analogs in maize (Zea mays L.) Theor Appl Genet. 113:63-72.
27. He Y, Han YP, Jiang L, Xu CW, Lu JF, Xu ML*. 2006. Functional analysis of starch-synthesis genes in determining rice eating and cooking qualities. Mol Breed 18:277-290.
28. Ji Q, Lu JF, Chao Q, Gu MH, Xu ML*. 2005. Delimiting a rice wide-compatibility gene S 5 n to a 50 kb region. Theor Appl Genet 111: 1495- 1503.
29. Xu ML, Li X and Korban SS, 2004. DNA methylation alterations and exchanges during in vitro cellular differentiation in rose (Rosa hybrida L.). Theor Appl Genet 109：899-910.
30. Xu ML and Korban SS, 2004. Somatic variation plays a key role in driving the evolution of the Vf gene family that confer resistance to apple scab disease. Molecular Phylogenetics and Evolution 32：57-65.
31. Huaracha, E.M., Xu ML, K. Gasic, E. Pauwels, A. van den Putte, J.W. Keulemans, and S.S. Korban. 2004. Phenotypic reaction and genetic analysis using AFLP-derived SCARs for resistance to apple scab. J. Phytopathology 152：260-266.
32. Han YP, Xu ML*, Liu XY, Yan CJ, Korban SS, Chen XL and Gu MH.2004. Genes coding for starch branching enzymes are major contributors to starch viscosity characteristics in waxy rice (Oryza sativa L.). Plant Science 166:357-364.
33. Liu XY, Gu MH, Han YP, Ji Q, Lu JF, Gu SL, Zhang R, Li X, Chen JM, Korban S S and Xu ML*. 2003. Developing gene-tagged molecular markers for functional analysis of starch-synthesizing genes in rice (Oryza Sativa L.). Euphytica 135:345-353.
34. Xu ML and Korban SS. 2003. Positional cloning of the apple scab resistance gene Vf. Proc. XXVII Intl. Hort. Cong. Acta Hort. 625:79-87.
35. Carr J, Xu ML and Korban SS. 2003. Estimating genetic diversity in New Guinea impatiens. Proc. XXVII Intl. Hort. Cong. 623:161-168.
36. Dußle C, Quin M, Melchinger AE, Xu ML and Luebberstedt T, 2003. Saturation of two chromosome regions conferring resistance to SCMV by targeted BSA. Theor Appl Genet 106:485-493.
37. Carr, J., Xu ML, J.W. Dudley, and S.S. Korban. 2003. AFLP analysis of genetic variability in New Guinea impatiens. Theor Appl Genet 106: 1509-1516.
38. Huaracha E, Xu ML, Pauwels E, Keulemans W and Korban SS, 2002. Comparison of marker-assisted selection and phenotypic selection for apple scab resistance in a set of apple progenies Theor Appl Genet 108:274-479.
39. Li XQ, Xu ML and Korban SS, 2002. DNA methylation profiles differ between field- and in vitro-grown leaves of apple. Journal of plant physiology 159:1229-1234.
40. Xu ML and Korban SS, 2002. A cluster of four active receptor-like genes reside in the Vf locus that confers resistance to apple scab disease. Genetics 162:1995-2006.
41. Dußle CM, Quint M, Xu ML, Melchinger AE and Luebberstedt T, 2002. Conversion of AFLP fragments tightly linked to SCMV resistance genes Scmv1 and Scmv2 into simple PCR-based markers. Theor Appl Genet 105: 1190-1195.
42. Quint M, Mihaljevic R, Dußle CM, Xu ML, Melchinger AE and Luebberstedt T, 2002. Genetic mapping of candidate genes for SCMV resistance in maize and conversion into RGA-CAPS markers. Theor Appl Genet 105:355-363.
43. Xu ML and Korban SS, 2002. AFLP-derived SCARs facilitate construction of a 1.1 Mb sequence-ready map of a region that spans the Vf locus in the apple genome. Plant Mol Biology 50: 803-818.
44. Korban SS and Xu ML, 2002. Going after the scab resistance gene. Trans. Ill. Hort. Soc. 134:15-20.
45. Xu ML, Korban SS, Song JQ, and Jiang JM 2002. Constructing a bacterial artificial chromosome library of the apple cultivar GoldRush. Acta Hort. 595:103-112.
46. Xu ML, Song JQ, Cheng ZK, Jiang JM and Korban SS, 2001. A bacterial artificial chromosome (BAC) library of Malus floribunda 821 and contig construction for positional cloning of the apple scab resistance gene Vf. Genome 44:1104-1113.
47. Xu ML, Huaracha E and Korban SS, 2001. Development of sequence-characterized amplified regions (SCARs) from amplified fragment length polymorphism (AFLP) markers tightly linked to the Vf gene in apple. Genome 44:63-70.
48. Xu ML, Li XQ and Korban SS, 2000. AFLP-based detection of DNA methylation. Plant Mol Biol Rep 18: 361-368.
49. Xu ML and Korban SS, 2000. Saturation mapping of the apple scab resistance gene Vf using AFLP markers. Theor Appl Genet 101: 844-851.
50. Xu ML, Melchinger AE and Luebberstedt T, 2000. Origin of Scm1 and Scm2 - two loci conferring resistance to sugarcane mosaic virus (SCMV)in maize. Theor Appl Genet 100: 934-941.
51. Luebberstedt T, Xia XC, Xu ML, Kuntze L, Melchinger AE, 1999. Inheritance of resistance to SCMV and MDMV in European maize. In: Proc. of the XVth EUCARPIA 1998 General Congress: Genetics and breeding for crop quality and resistance, G.T.S. Mugnozza (ed.), pp. 241-250 Kluwer
Academic Publishers, Dordrecht, The Netherlands
52.Xu ML, Melchinger AE, Xia XC and Luebberstedt T, 1999. High-resolution mapping of loci conferring resistance to sugarcane mosaic virus in maize using RFLP, SSR, and AFLP markers. Mol Gen Genet 261: 574-581.
53.Xu ML, Melchinger AE and Luebberstedt T, 1999. Species-specific detection of the maize pathogens Sporisorium reiliana and Ustilago maydis by dot blot hybridization and PCR-based assays. Plant Dis 83: 390-395.

課題組簡介

課題組成員：

教授：徐明良

副教授：葉建榮

科研助理：李茜

博士後：冷鵬飛

在讀博士生：馬傳禹、劉慶彩、李懿璞、鍾濤、張博琦、朱芒、劉建菊、張倩倩、龔央慶、鄧穗寧、姚麗姍

在讀碩士生：鄧樂樂、童立秀、王利娜、杜腓利、於輝、漢和鈺

課題組研究進展：

絲黑穗病：

課題組發展出了利用重組個體後代測定的QTL連續精細定位和克隆策略。並利用這一策略在玉米第2染色體上檢測到了一個抗絲黑穗病主效QTL，能顯著提高25%的抗病率。

首次完整報導了玉米抗病QTL的克隆和抗病機理的研究，為揭示異化授粉玉米特有的抗病機制奠定了基礎。在實踐中，通過分子標記輔助導入該基因能夠顯著提高玉米對絲黑穗病的抗性，具有巨大的套用價值。合作單位吉林省農科院玉米所檀國慶研究員利用ZmWAK基因培育出生產潛力大，高抗的吉單系列品種，已在生產上推廣套用。

在莖腐病、甘蔗花葉病毒病、粗縮病、灰斑病等病害研究也取得較大進展。

徐明良[中國農業大學教授]

人物簡介

個人簡歷

教學工作

研究方向

主要成就

出版著作

課題組簡介

課題組成員：

課題組研究進展：

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