基本信息
丁梅
職稱：研究員
研究方向：神經系統發育的分子機制
丁梅 博士 研究員 博士生導師
1995年廈門大學學士， 2004年美國加州大學聖克魯斯分校(University of California, Santa Cruz)獲博士學位，2004至2008年美國史丹福大學(Stanford University)博士後。2008年任中國科學院遺傳與發育生物學研究所研究員，百人計畫，博士生導師。
研究方向
人類感知、學習、記憶、思維、情緒均依賴於神經系統正確的信號傳導。然而，神經系統信號傳導究竟如何發生，是什麼機制確保信息傳導的連貫性和精確性並不清楚。本實驗室立足基礎，以秀麗隱桿線蟲為模式，綜合利用分子生物學，遺傳學，活體成像，生物化學等多種研究手段， 系統探索神經系統發育的分子機制。主要研究內容包括：軸突定向生長，神經細胞特異性識別，突觸形成與穩態調控。
發表論文
1. Guan L*, Ma X*, Zhang J, Liu J, Wang Y, Ding M#. The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions
2.Wu J, Cheng Y, Wang J, Chen L, Ding M, and Wu J.(2015) Structural insight into the mechanism of synergic autoinhibition of SAD kinases
3. Cheng Y*, Wang J*, WangY, and Ding M#. (2015) Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle
4. Wang J, Chitturi J, Ge Q, Laskova V, Wang W, Li X, Ding M, Zhen M# and Huang X#. (2015) The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage
5. Qin J, Liang J, and Ding M#. (2014) Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons
6. Zhang J, Li X, Jevince AR, Guan L, Wang J, Hall DH, Huang X #, and Ding M#. (2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C
7. Song S*, Zhang B*, Sun H, Li X, Xiang Y, Liu Z, Huang X #, and Ding M#. (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans
8. Ding M # and Shen K. (2008) The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases
9. Ding M, King RS, Berry EC, Wang Y, Hardin J, and Chisholm AD. (2008) The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19
10. Ding M, Chao D, Wang G, Shen K. (2007) Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination
11. Ding M, Woo WM, Chisholm AD. (2004) The cytoskeleton and epidermal morphogenesis in C
12. Ding M, Goncharov A, Jin Y, Chisholm AD. (2003) C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis
13. Chin-Sang ID, Moseley SL, Ding M, Harrington RJ, George SE, Chisholm AD. (2002). The divergent C. elegans ephrin EFN-4 functions in embryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor
14. Chin-Sang ID, George SE, Ding M, Moseley SL, Lynch AS, Chisholm AD. (1999) The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C
